Evidence map›Paper›PMID 30781660›Full record

ReviewJournal of clinical medicine2019

The Emerging Role of Robotic Surgery among Minimally Invasive Surgical Approaches in the Treatment of Hypopharyngeal Carcinoma: Systematic Review and Meta-Analysis.

Armando De Virgilio, Oreste Iocca, Luca Malvezzi, Pasquale Di Maio, Raul Pellini, Fabio Ferreli, Giovanni Cugini, Giovanni Colombo, Giuseppe Spriano

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Transoral robotic surgery in head and neck cancer: an umbrella review of meta-analyses.International journal of surgery (London, England) · 2026
    Article
  5. Review
  6. Article
  7. Enhanced recovery after surgery: a prospective cohort study on ibSLN preservation in transoral laser surgery for pyriform sinus carcinoma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Lateral conservative approach for recurrent/persistent hypopharyngeal carcinoma: a case series.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Armando De VirgilioOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy. armando.devirgilio@gmail.com.ORCID 0000-0003-0738-8223
Oreste IoccaOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy. oi243@nyu.edu.
Luca MalvezziOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy. luca.malvezzi@humanitas.it.
Pasquale Di MaioOtorhinolaryngology Unit, Department of Surgical ad Biomedical Sciences, University of Perugia, Piazza dell'Università, 1, 06123 Perugia, Italy. dimaio.p86@alice.it.ORCID 0000-0003-1364-9223
Raul PelliniDepartment of Otolaryngology-Head and Neck Surgery, Regina Elena National Cancer Institute, 00144 Rome, Italy. pelliniraul@yahoo.it.ORCID 0000-0001-6051-3041
Fabio FerreliOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy. fabio.ferreli@humanitas.it.
Giovanni CuginiOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy. giovanni.cugini@humanitas.it.
Giovanni ColomboOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy. giovanni.colombo@humanitas.it.
Giuseppe SprianoOtorhinolaryngology Unit, Humanitas University, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy. giuseppe.spriano@hunimed.eu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) check-list, and 15 studies were included. Five of the included studies evaluated TORS, while ten studies focused on transoral laser microsurgery (TLM) for the treatment of early or advanced stage hypopharyngeal cancer. Overall, survival rates of TLM and TORS studies, analyzed together in the cumulative meta-analysis, were 66.4% (95% confidence interval (CI) 54.3%⁻76.7%) at 36+ months of follow up. The TORS subgroup showed a higher cumulative survival rate (85.5%, 95% CI 55.8%⁻96.5%) compared to TLM (58.5%, 95% CI 46.6%⁻69.6%). Cumulative data showed that 29.3% (95% CI 24.0%⁻35.3%) of deaths were attributable to cancer. The results were similar between TLM and TORS studies. The larynx function preservation cumulative rate was 94.3% (95% CI 91.8%⁻96.1%). The results were similar among the two subgroups. The present review supports the use of transoral approaches in the treatment of hypopharyngeal cancer. TORS is oncologically sound and provides excellent functional results with low complication rates.

Indexed as

hypopharynxpharynxrobotic surgeryTORStransoral surgery

Identifiers

PMID30781660
PMCPMC6406881

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.