Evidence map›Paper›PMID 30781627›Full record

ArticleBiosensors2019

Toward Highly Efficient Cancer Imaging and Therapy Using the Environment-Friendly Chitosan Nanoparticles and NIR Laser.

Hala S Abuelmakarem, Mahmoud A Sliem, Jala El-Azab, Moustafa M A Farghaly, Wafaa A Ahmed

Abstract read
In one paragraph

Article in Biosensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hala S AbuelmakaremSystem and Biomedical Engineering Department, The Higher Institute of Engineering, El Shorouk City, Cairo 11837, Egypt. h.saad@sha.edu.eg.
Mahmoud A SliemDepartment of Laser Applications in Metrology, Photochemistry and Agriculture (LAMPA), National Institute of Laser Enhanced Sciences (NILE), Cairo University, Giza 12613, Egypt. mahmoud.ashour@rub.de.
Jala El-AzabDepartment of Engineering Applications of Laser, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Giza 12613, Egypt. jala@niles.edu.eg.ORCID 0000-0003-3583-0955
Moustafa M A FarghalySystem and Biomedical Engineering Department, The Higher Institute of Engineering, El Shorouk City, Cairo 11837, Egypt. mousfar@hotmail.com.
Wafaa A AhmedCancer Biology Department, Biochemistry and Molecular Biology Unit, National Cancer Institute, Cairo University, Giza 11796, Egypt. drwafaaeg@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chitosan-tripolyphosphate nanoparticles (C-TPP NPs) were synthesized to investigate their cytotoxicity against colon cancer cells (Caco2 cells) in the absence and the presence of a near-infrared (NIR) laser to evaluate their influence in cancer detection using the NIR laser and to evaluate the NIR laser on cancer treatment. The synthesized NPs were characterized by Fourier transform infrared (FT-IR) spectroscopy, dynamic light scattering (DLS), zeta potential (ZP), and transmission electronic microscope (TEM). The cytotoxicity was analyzed by the MTT test and the cell viability was assessed using the Trypan blue method. C-TPP NPs showed increased cytotoxicity and decreased cell viability against Caco2 cells. Upon laser exposure only, the cell viability decreased. The C-TPP NPs appeared to have a shining light on the cancerous cells which were photographed under the inverted microscope.

Indexed as

LasersSpectroscopy, Near-InfraredCaco-2 CellsCell SurvivalChitosanGreen Chemistry TechnologyHumansInhibitory Concentration 50NanoparticlesNeoplasmsParticle SizeSpectroscopy, Fourier Transform InfraredStatic ElectricityChitosanChitosancytotoxicitynanoparticlesNIRoptical imaging

Identifiers

PMID30781627
PMCPMC6469023

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.