Evidence map›Paper›PMID 30781626›Full record

ArticleInternational journal of molecular sciences2019

Hippocampal

Iván Méndez-López, Idoia Blanco-Luquin, Javier Sánchez-Ruiz de Gordoa, Amaya Urdánoz-Casado, Miren Roldán, Blanca Acha, Carmen Echavarri, Victoria Zelaya, Ivonne Jericó, Maite Mendioroz

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Iván Méndez-LópezNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. imendezl@navarra.es.
Idoia Blanco-LuquinNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. idoia.blanco.luquin@navarra.es.
Javier Sánchez-Ruiz de GordoaNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. jsruizdegordoa@gmail.com.
Amaya Urdánoz-CasadoNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. aurdanoz.1@gmail.com.
Miren RoldánNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. miren.roldan.arrastia@navarra.es.
Blanca AchaNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. blancacha02@hotmail.com.
Carmen EchavarriNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. carmentxu.ez@gmail.com.
Victoria ZelayaDepartment of Pathology, Complejo Hospitalario de Navarra- IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. mv.zelaya.huerta@navarra.es.
Ivonne JericóDepartment of Neurology, Complejo Hospitalario de Navarra- IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. ivonne.jerico.pascual@navarra.es.
Maite MendiorozNeuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain. maitemendilab@gmail.com.ORCID 0000-0002-4179-5781
Universidad Publica de Navarra · ESComplejo Hospitalario de Navarra · ES

Funding

Departamento de Industria-Gobierno de Navarra AUCEusko Jaurlaritza BIO12/ALZ/007Fundación Caja Navarra EPIBIODInstituto de Salud Carlos III FIS PI13/02730"la Caixa" Foundation Intensificación NavarrabiomedTrans-Pyrenean Biomedical Research Network (REFBIO) EPIBIOD
6 · The paper itself

Abstract

Lamins are fibrillary proteins that are crucial in maintaining nuclear shape and function. Recently, B-type lamin dysfunction has been linked to tauopathies. However, the role of A-type lamin in neurodegeneration is still obscure. Here, we examined A-type and B-type lamin expression levels by RT-qPCR in Alzheimer's disease (AD) patients and controls in the hippocampus, the core of tau pathology in the brain.

Indexed as

Gene Expression RegulationAdultAgedAged, 80 and overAge FactorsAlzheimer DiseaseFemaleHippocampusHumansLamin Type AMaleMiddle AgedPhosphorylationRNA, Messengertau ProteinsLamin Type ARNA, Messengertau ProteinsagingAlzheimer’s diseasehippocampuslamin Alamin ClaminsLMNAtauopathy

Identifiers

PMID30781626
PMCPMC6413092
OpenAlexW2911360534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.