ArticleNanomaterials (Basel, Switzerland)2019
A Smart Nanovector for Cancer Targeted Drug Delivery Based on Graphene Quantum Dots.
Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- EnterohemorrhagicACS omega · 2026Article
- Graphene Dot-ZnO Hybrid Nanostructures as High-Performance Chemiresistive Sensors for HACS omega · 2026Article
- Sorption processes of wastewater contaminants on virgin and aged polystyrene microplastics: physicochemical changes and cellular toxicity assessment.Archives of toxicology · 2025Article
- N-Amino Peptide-Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies.Advanced nanobiomed research · 2025Article
- Recent Advancements in Graphene Quantum Dot-Based Bioimaging and Drug Delivery Systems.MedComm · 2025Review
- Review
- Development of advanced drug-loaded graphene quantum dots with improved photoluminescence properties for enhanced targeted therapy and nano-imaging technologies.RSC advances · 2025Article
- Review
- A New Approach in the Early Electrochemical Diagnosis of Hepatitis B Virus Infection using Carbon-based Nanomaterials.Recent patents on nanotechnology · 2025Review
- Recent Biomedical Applications of Carbon Quantum Dots in Cancer Treatment.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Graphene Quantum Dots from Natural Carbon Sources for Drug and Gene Delivery in Cancer Treatment.International journal of molecular sciences · 2024Review
- Theoretical Analysis of Riboflavin Adsorption on Hexagonal Boron Nitride for Drug Delivery Applications: Unveiling the Influence of Point Defects.International journal of molecular sciences · 2023Article
- Clindamycin-Loaded Nanosized Calcium Phosphates Powders as a Carrier of Active Substances.Nanomaterials (Basel, Switzerland) · 2023Article
- Specific Forms of Graphene Quantum Dots Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells.International journal of molecular sciences · 2023Article
- Nanomaterials and Their Impact on the Immune System.International journal of molecular sciences · 2023Review
- Article
- Orange-Peel-Derived Nanobiochar for Targeted Cancer Therapy.Pharmaceutics · 2022Article
- Nanocarrier cancer therapeutics with functional stimuli-responsive mechanisms.Journal of nanobiotechnology · 2022Review
- Targeted Delivery Methods for Anticancer Drugs.Cancers · 2022Review
- Biomedical Applications of Quantum Dots: Overview, Challenges, and Clinical Potential.International journal of nanomedicine · 2022Review
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Graphene quantum dots (GQD), the new generation members of graphene-family, have shown promising applications in anticancer therapy. In this study, we report the synthesis of a fluorescent and biocompatible nanovector, based on GQD, for the targeted delivery of an anticancer drug with benzofuran structure (BFG) and bearing the targeting ligand riboflavin (RF, vitamin B2). The highly water-dispersible nanoparticles, synthesized from multi-walled carbon nanotubes (MWCNT) by prolonged acidic treatment, were linked covalently to the drug by means of a cleavable PEG linker while the targeting ligand RF was conjugated to the GQD by π⁻π interaction using a pyrene linker. The cytotoxic effect of the synthesized drug delivery system (DDS) GQD-PEG-BFG@Pyr-RF was tested on three cancer cell lines and this effect was compared with that exerted by the same nanovector lacking the RF ligand (GQD-PEG-BFG) or the anticancer drug (GQD@Pyr-RF). The results of biological tests underlined the low cytotoxicity of the GQD sample and the cytotoxic activity of the DDS against the investigated cancer cell lines with a higher or similar potency to that exerted by the BFG alone, thus opening new possibilities for the use of this drug or other anticancer agents endowed of cytotoxicity and serious side effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.