Evidence map›Paper›PMID 30781586›Full record

ArticleCells2019

CVm6A: A Visualization and Exploration Database for m⁶As in Cell Lines.

Yujing Han, Jing Feng, Linjian Xia, Xin Dong, Xinyang Zhang, Shihan Zhang, Yuqi Miao, Qidi Xu, Shan Xiao, Zhixiang Zuo and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 50 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. METTL3-mediated mMolecular biology reports · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. New insights on the interplays between mFrontiers in cell and developmental biology · 2023
    Review
  10. Review
  11. Article
  12. Review
  13. Novel insight into the functions of NInternational journal of oncology · 2022
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yujing HanSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. hanyujing@whu.edu.cn.
Jing FengSchool of Computer Science, Wuhan University, Wuhan 430072, Hubei, China. gfeng@whu.edu.cn.
Linjian XiaSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. linjianxia@whu.edu.cn.ORCID 0000-0003-1523-2958
Xin DongSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. dongxin@whu.edu.cn.
Xinyang ZhangSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. zhangxinyang@whu.edu.cn.
Shihan ZhangSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. 13699447096@163.com.
Yuqi MiaoSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. myq_victoria@163.com.
Qidi XuSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. xuqidi01@outlook.com.
Shan XiaoDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. asdfg@smu.edu.cn.
Zhixiang ZuoSun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University, Guangzhou 510060, China. zuozhx@sysucc.org.cn.
Laixin XiaDepartment of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. xialx@smu.edu.cn.
Chunjiang HeSchool of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China. che@whu.edu.cn.ORCID 0000-0002-4868-331X
Wuhan University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N6-methyladenosine (m⁶A) has been identified in various biological processes and plays important regulatory functions in diverse cells. However, there is still no visualization database for exploring global m⁶A patterns across cell lines. Here we collected all available MeRIP-Seq and m⁶A-CLIP-Seq datasets from public databases and identified 340,950 and 179,201 m⁶A peaks dependent on 23 human and eight mouse cell lines respectively. Those m⁶A peaks were further classified into mRNA and lncRNA groups. To better understand the potential function of m⁶A, we then mapped m⁶A peaks in different subcellular components and gene regions. Among those human m⁶A modification, 190,050 and 150,900 peaks were identified in cancer and non-cancer cells, respectively. Finally, all results were integrated and imported into a visualized cell-dependent m⁶A database CVm6A. We believe the specificity of CVm6A could significantly contribute to the research for the function and regulation of cell-dependent m⁶A modification in disease and development.

Indexed as

Databases as TopicAdenosineAnimalsCell LineHumansInternetMiceUser-Computer InterfaceAdenosineN-methyladenosinecell linem6AN6-methyladenosinevisualization

Identifiers

PMID30781586
PMCPMC6406471
OpenAlexW2914289736

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.