Evidence map›Paper›PMID 30781345›Full record

ArticleInternational journal of molecular sciences2019

Radiobiological Characterization of Canine Malignant Melanoma Cell Lines with Different Types of Ionizing Radiation and Efficacy Evaluation with Cytotoxic Agents.

Hiroto Yoshikawa, Shigeaki Sunada, Hirokazu Hirakawa, Akira Fujimori, Suad Elmegerhi, Del Leary, Takamitsu A Kato

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. From Basic Radiobiology to Translational Radiotherapy.International journal of molecular sciences · 2022
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Hiroto YoshikawaDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA. hyoshik@ncsu.edu.ORCID 0000-0001-8249-1525
Shigeaki SunadaDepartment of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113-8510, Japan. sunada.mgen@mri.tmd.ac.jp.
Hirokazu HirakawaDepartment of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba 263-8555, Japan. hirakawa.hirokazu@qst.go.jp.
Akira FujimoriDepartment of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Chiba 263-8555, Japan. fujimori.akira@qst.go.jp.
Suad ElmegerhiDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. hanoyara@rams.colostate.edu.
Del LearyDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. Del.Leary@colostate.edu.
Takamitsu A KatoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA. tkato@rams.colostate.edu.ORCID 0000-0002-6263-600X
Colorado State University · USNorth Carolina State University · USTokyo Medical and Dental University · JP

Funding

Dr. Akiko Ueno Radiobiology Research Fund NAJapan Ministry of Education, Culture, Sports, Science and Technology (MEXT) Grants-in-Aid for Scientific Research on Innovative Areas JP15K21745
6 · The paper itself

Abstract

Canine malignant melanoma (CMM) is a locally and systemically aggressive cancer that shares many biological and clinical characteristics with human mucosal melanoma. Hypofractionated radiation protocols have been used to treat CMM but little is known about its radiation biology. This pilot study is designed to investigate response of CMM cell lines to various ionizing radiations and cytotoxic agents to better understand this canine cancer. Four CMM cell lines were evaluated by clonogenic survival assay under aerobic and hypoxic conditions and parameters such as alpha beta (α/β) ratio, oxygen enhancement ratio (OER), and relative biological effectiveness (RBE) were calculated after

Indexed as

Radiation, IonizingAnimalsCell DeathCell Line, TumorCell SurvivalClone CellsCytotoxinsDogsMelanomaOxygenRelative Biological EffectivenessSurvival AnalysisTreatment OutcomeCytotoxinsOxygencanine malignant melanomacarbon ionionizing radiationphotontumor hypoxia

Identifiers

PMID30781345
PMCPMC6413050
OpenAlexW2911791884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.