Evidence map›Paper›PMID 30780246›Full record

ArticlePhysical review. E2019

Cell geometry and leaflet bilayer asymmetry regulate domain formation in plasma membranes.

Md Zulfikar Ali, Kerwyn Casey Huang, Ned S Wingreen, Ranjan Mukhopadhyay

Abstract read
In one paragraph

Article in Physical review. E, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Md Zulfikar AliDepartment of Physics, Clark University, Worcester, Massachusetts 01610, USA.
Kerwyn Casey HuangDepartment of Bioengineering, Stanford University, Stanford, California 94305, USA.
Ned S WingreenDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA.
Ranjan MukhopadhyayDepartment of Physics, Clark University, Worcester, Massachusetts 01610, USA.

Funding

Thermally robust chemotaxis and thermotaxis in Escherichia coliR01GM082938 · NIGMS · PRINCETON UNIVERSITY · PI WINGREEN, NED S · 2008 to 2025
$5.5M
NIGMS NIH HHS R01 GM082938
6 · The paper itself

Abstract

We model how pattern formation in a multicomponent lipid bilayer pinned to an elastic substrate is governed by the interplay between lipid phase separation and the tendency of domains of high intrinsic curvature lipids to deform the membrane away from a stiff substrate such as the cell wall. The emergent patterns, which include compact and striped lipid microdomains, are anticorrelated across the two leaflets and depend on leaflet asymmetry, the ability of lipids to flip between leaflets, and the global geometry. We characterize analytically the dependence of stripe width on lipid parameters, and consider the implications of interleaflet patterning for curvature-dependent lipid localization.

Identifiers

PMID30780246
PMCPMC6553634

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.