ReviewDevelopment, growth & differentiation2019
Dynamics of transcriptional enhancers and chromosome topology in gene regulation.
Review in Development, growth & differentiation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Unraveling the regulatory dynamics of bidirectional promoters for modulating gene co-expression and metabolic flux in Saccharomyces cerevisiae.Nucleic acids research · 2025Article
- From genes to patterns: a framework for modeling the emergence of embryonic development from transcriptional regulation.Frontiers in cell and developmental biology · 2025Article
- GEEES: inferring cell-specific gene-enhancer interactions from multi-modal single-cell data.Bioinformatics (Oxford, England) · 2024Article
- Chromosome structure modeling tools and their evaluation in bacteria.Briefings in bioinformatics · 2024Review
- Distinct roles for CKM-Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction.Nature structural & molecular biology · 2022Article
- Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge.Molecular psychiatry · 2022Article
- Independence of chromatin conformation and gene regulation during Drosophila dorsoventral patterning.Nature genetics · 2021Article
- Computational Screening of Phase-separating Proteins.Genomics, proteomics & bioinformatics · 2021Review
- The 3D Genome as a Target for Anticancer Therapy.Trends in molecular medicine · 2020Review
- Article
- Dynamics of transcriptional enhancers and chromosome topology in gene regulation.Development, growth & differentiation · 2019Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Transcriptional enhancers are regulatory DNAs that instruct when and where genes should be transcribed in response to a variety of intrinsic and external signals. They contain a cluster of binding sites for sequence-specific transcription factors and co-activators to determine the spatiotemporal specificity of gene activities during development. Enhancers are often positioned in distal locations from their target promoters. In some cases, they work over a million base pairs or more. In the traditional view, enhancers have been thought to stably interact with promoters in a targeted manner. However, quantitative imaging studies provide a far more dynamic picture of enhancer action. Moreover, recent Hi-C methods suggest that regulatory interactions are dynamically regulated by the higher-order chromosome topology. In this review, we summarize the emerging findings in the field and propose that assembly of "transcription hubs" in the context of 3D genome structure plays an important role in transcriptional regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.