ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019
Cannabis use in youth is associated with limited alterations in brain structure.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuropsychological effects of cannabis use by continent and age: a systematic review.Frontiers in psychology · 2026Pooled it
- Effects of Cannabis Exposure on Adolescent Health and Development: A Narrative Review.Current drug research reviews · 2025Review
- Cannabis use in adolescence and young adulthood and its effects on brain structure and function: a scoping review.Frontiers in psychiatry · 2025Review
- Cells and Molecules Underpinning Cannabis-Related Variations in Cortical Thickness during Adolescence.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Abnormal developmental of structural covariance networks in young adults with heavy cannabis use: a 3-year follow-up study.Translational psychiatry · 2024Article
- The Effect of Oil-Based Cannabis Extracts on Metabolic Parameters and Microbiota Composition of Mice Fed a Standard and a High-Fat Diet.International journal of molecular sciences · 2024Article
- The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice.International journal of molecular sciences · 2023Article
- Intersection between social inequality and emotion regulation on emerging adult cannabis use.Drug and alcohol dependence reports · 2022Article
- The stoned age: Sex differences in the effects of adolescent cannabinoid exposure on prefrontal cortex structure and function in animal models.International review of neurobiology · 2022Review
- Exploring relationships between alcohol consumption, inflammation, and brain structure in a heavy drinking sample.Alcoholism, clinical and experimental research · 2021Article
- Associations of cannabis use disorder with cognition, brain structure, and brain function in African Americans.Human brain mapping · 2021Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Changes in cannabis use, exposure, and health perceptions following legalization of adult recreational cannabis use in California: a prospective observational study.Substance abuse treatment, prevention, and policy · 2021Observational
- Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women.Frontiers in psychiatry · 2021Article
- Trends of the incidence of drug use disorders from 1990 to 2017: an analysis based on the Global Burden of Disease 2017 data.Epidemiology and psychiatric sciences · 2020Article
- Importance of a standard unit dose for cannabis research.Addiction (Abingdon, England) · 2020Article
- Recent tobacco use has widespread associations with adolescent white matter microstructure.Addictive behaviors · 2020Article
- Adolescent Substance Use and the Brain: Behavioral, Cognitive and Neuroimaging Correlates.Frontiers in human neuroscience · 2020Article
- A Roadmap for Integrating Neuroscience Into Addiction Treatment: A Consensus of the Neuroscience Interest Group of the International Society of Addiction Medicine.Frontiers in psychiatry · 2019Review
- Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives.The American journal of drug and alcohol abuse · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Frequent cannabis use during adolescence has been associated with alterations in brain structure. However, studies have featured relatively inconsistent results, predominantly from small samples, and few studies have examined less frequent users to shed light on potential brain structure differences across levels of cannabis use. In this study, high-resolution T1-weighted MRIs were obtained from 781 youth aged 14-22 years who were studied as part of the Philadelphia Neurodevelopmental Cohort. This sample included 147 cannabis users (109 occasional [≤1-2 times per week] and 38 frequent [≥3 times per week] users) and 634 cannabis non-users. Several structural neuroimaging measures were examined in whole brain analyses, including gray and white matter volumes, cortical thickness, and gray matter density. Established procedures for stringent quality control were conducted, and two automated neuroimaging software processing packages were used to ensure robustness of results. There were no significant differences by cannabis group in global or regional brain volumes, cortical thickness, or gray matter density, and no significant group by age interactions were found. Follow-up analyses indicated that values of structural neuroimaging measures by cannabis group were similar across regions, and any differences among groups were likely of a small magnitude. In sum, structural brain metrics were largely similar among adolescent and young adult cannabis users and non-users. Our data converge with prior large-scale studies suggesting small or limited associations between cannabis use and structural brain measures in youth. Detailed studies of vulnerability to structural brain alterations and longitudinal studies examining long-term risk are clearly indicated.
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Registered trials
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