ArticleNMR in biomedicine2019
VERDICT MRI validation in fresh and fixed prostate specimens using patient-specific moulds for histological and MR alignment.
Article in NMR in biomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Characterizing the Diffusion Properties of Prostate Tissue Using Paired MR Microscopy and Multidimensional Diffusion MRI.Magnetic resonance in medicine · 2026Article
- Microstructure imaging of prostate cancer by diffusion MRI.Magma (New York, N.Y.) · 2026Review
- Cluster Analysis of VERDICT MRI for Cancer Tissue Characterization in Neuroendocrine Tumors.NMR in biomedicine · 2025Article
- Assessing tumor microstructure with time-dependent diffusion imaging: Considerations and feasibility on clinical MRI and MRI-Linac.Medical physics · 2025Article
- Joint estimation of compartment-specific TMagnetic resonance in medicine · 2025Article
- Significance of multi-task deep learning neural networks for diagnosing clinically significant prostate cancer in plain abdominal CT.Frontiers in oncology · 2025Article
- MRI-based virtual pathology of the prostate.Magma (New York, N.Y.) · 2024Review
- Radiology and multi-scale data integration for precision oncology.NPJ precision oncology · 2024Review
- Metabolic imaging across scales reveals distinct prostate cancer phenotypes.Nature communications · 2024Article
- Prostate Cancers Invisible on Multiparametric MRI: Pathologic Features in Correlation with Whole-Mount Prostatectomy.Cancers · 2023Article
- Test-retest repeatability of ADC in prostate using the multi b-Value VERDICT acquisition.European journal of radiology · 2023Article
- Joint estimation of relaxation and diffusion tissue parameters for prostate cancer with relaxation-VERDICT MRI.Scientific reports · 2023Article
- Emerging MR methods for improved diagnosis of prostate cancer by multiparametric MRI.Magma (New York, N.Y.) · 2022Review
- Observational
- Validation of Prostate Tissue Composition by Using Hybrid Multidimensional MRI: Correlation with Histologic Findings.Radiology · 2022Article
- Emerging methods for prostate cancer imaging: evaluating cancer structure and metabolic alterations more clearly.Molecular oncology · 2021Review
- MR cell size imaging with temporal diffusion spectroscopy.Magnetic resonance imaging · 2021Review
- New prostate MRI techniques and sequences.Abdominal radiology (New York) · 2020Review
- A multimodal computational pipeline for 3D histology of the human brain.Scientific reports · 2020Article
- VERDICT MRI validation in fresh and fixed prostate specimens using patient-specific moulds for histological and MR alignment.NMR in biomedicine · 2019Article
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Authors and funding
17 authors at 6 institutions in 4 countries.
Funding
Abstract
The VERDICT framework for modelling diffusion MRI data aims to relate parameters from a biophysical model to histological features used for tumour grading in prostate cancer. Validation of the VERDICT model is necessary for clinical use. This study compared VERDICT parameters obtained ex vivo with histology in five specimens from radical prostatectomy. A patient-specific 3D-printed mould was used to investigate the effects of fixation on VERDICT parameters and to aid registration to histology. A rich diffusion data set was acquired in each ex vivo prostate before and after fixation. At both time points, data were best described by a two-compartment model: the model assumes that an anisotropic tensor compartment represents the extracellular space and a restricted sphere compartment models the intracellular space. The effect of fixation on model parameters associated with tissue microstructure was small. The patient-specific mould minimized tissue deformations and co-localized slices, so that rigid registration of MRI to histology images allowed region-based comparison with histology. The VERDICT estimate of the intracellular volume fraction corresponded to histological indicators of cellular fraction, including high values in tumour regions. The average sphere radius from VERDICT, representing the average cell size, was relatively uniform across samples. The primary diffusion direction from the extracellular compartment of the VERDICT model aligned with collagen fibre patterns in the stroma obtained by structure tensor analysis. This confirmed the biophysical relationship between ex vivo VERDICT parameters and tissue microstructure from histology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.