ArticlePloS one2019
Immune-enhancing effects of anionic macromolecules extracted from Codium fragile on cyclophosphamide-treated mice.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
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- Immunomodulatory activity of semen Ziziphi Spinosae protein: a potential plant protein functional food raw material.NPJ science of food · 2023Article
- Sulfated Polysaccharide Extracted from the Green AlgaeMarine drugs · 2022Article
- Immunoenhancing Effects ofJournal of microbiology and biotechnology · 2022Article
- SBT (Composed ofAntioxidants (Basel, Switzerland) · 2022Article
- A concise review of the bioactivity and pharmacological properties of the genusJournal of applied phycology · 2022Review
- Enhancement of Immune Activities of Mixtures withFoods (Basel, Switzerland) · 2020Article
- Co-immunomodulatory Activities of Anionic Macromolecules Extracted fromJournal of microbiology and biotechnology · 2020Article
- The complete plastid genome and phylogenetic analysis ofMitochondrial DNA. Part B, Resources · 2020Article
- Effects of Polysaccharide fromOxidative medicine and cellular longevity · 2020Article
- Characterization and Immunomodulatory Effects of High Molecular Weight Fucoidan Fraction from the Sporophyll ofMarine drugs · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune-regulation and homeostasis are critical in cancer therapy and immunomodulatory biomaterials have been used to decrease side effects of immunosuppressant drugs. Anionic macromolecules (CFAMs) were isolated from the seaweed Codium fragile, and its immune-enhancing biological activities were examined in CY-induced immunosuppressed mice. CFAMs improved the splenic lymphocyte proliferation, NK cell activity, and spleen index. The expression of immune-associated genes was highly upregulated in splenic lymphocytes, and gene expression was differently regulated according to mitogens such as T-cell (Con A) and B-cell (LPS) mitogens. Additionally, CFAMs boosted the proliferation, NO production, and phagocytosis of peritoneal macrophages. CFAMs also considerably stimulated immune-associated gene expression in peritoneal macrophages. Moreover, our results showed CFAMs mediated its immune-enhancing effects via the MAPK pathway. These suggested CFAMs can be used as a potent immunomodulatory material under immune-suppressive condition. Furthermore, CFAMs may also be used as a bio-functional and pharmaceutical material for improving human health and immunity.
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