ArticlePloS one2019
Predicting cognitive resilience from midlife lifestyle and multi-modal MRI: A 30-year prospective cohort study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Resilience Shields and Grit Intensifies Subjective Cognitive Decline in Middle-To-Older Aged Black Americans.International journal of geriatric psychiatry · 2026Article
- Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.Alzheimer's research & therapy · 2024Article
- Cognitive resilience and severe Alzheimer's disease neuropathology.Aging brain · 2023Article
- Psychological resilience and work engagement of Chinese nurses: a chain mediating model of career identity and quality of work life.Frontiers in psychology · 2023Article
- Machine Learning Decomposition of the Anatomy of Neuropsychological Deficit in Alzheimer's Disease and Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Musicianship-Related Structural and Functional Cortical Features Are Preserved in Elderly Musicians.Frontiers in aging neuroscience · 2022Article
- Association between social supports and negative emotions among pediatric residents in China: The chain-mediating role of psychological resilience and burnout.Frontiers in public health · 2022Article
- Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults.Alzheimer's research & therapy · 2021Article
- Investigating Predictors of Preserved Cognitive Function in Older Women Using Machine Learning: Women's Health Initiative Memory Study.Journal of Alzheimer's disease : JAD · 2021Article
- Positive Effects of Education on Cognitive Functioning Depend on Clinical Status and Neuropathological Severity.Frontiers in human neuroscience · 2021Article
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThere is significant heterogeneity in the clinical expression of structural brain abnormalities, including Alzheimer's disease biomarkers. Some individuals preserve their memory despite the presence of risk factors or pathological brain changes, indicating resilience. We aimed to test whether resilient individuals could be distinguished from those who develop cognitive impairment, using sociodemographic variables and neuroimaging.
methodsWe included 550 older adults participating in the Whitehall II study with longitudinal data, cognitive test results, and multi-modal MRI. Hippocampal atrophy was defined as Scheltens Scores >0. Resilient individuals (n = 184) were defined by high cognitive performance despite hippocampal atrophy (HA). Non-resilient participants (n = 133) were defined by low cognitive performance (≥1.5 standard deviations (S.D.) below the group mean) in the presence of HA. Dynamic and static exposures were evaluated for their ability to predict later resilience status using multivariable logistic regression. In a brain-wide analysis we tested for group differences in the integrity of white matter (structural connectivity) and resting-state networks (functional connectivity).
findingsYounger age (OR: 0.87, 95% CI: 0.83 to 0.92, p<0.001), higher premorbid FSIQ (OR: 1.06, 95% CI: 1.03 to 1.10, p<0.0001) and social class (OR 1 vs. 3: 4.99, 95% CI: 1.30 to 19.16, p = 0.02, OR 2 vs. 3: 8.43, 95% CI: 1.80 to 39.45, p = 0.007) were independently associated with resilience. Resilient individuals could be differentiated from non-resilient participants by higher fractional anisotropy (FA), and less association between anterior and posterior resting state networks. Higher FA had a significantly more positive effect on cognitive performance in participants with HA, compared to those without.
conclusionsResilient individuals could be distinguished from those who developed impairments on the basis of sociodemographic characteristics, brain structural and functional connectivity, but not midlife lifestyles. There was a synergistic deleterious effect of hippocampal atrophy and poor white matter integrity on cognitive performance. Exploiting and supporting neural correlates of resilience could offer a fresh approach to postpone or avoid the appearance of clinical symptoms.
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