ArticlePloS one2019
Gender based survival prediction models for heart failure patients: A case study in Pakistan.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- GBC-AST: a cluster-based oversampling method for heart failure prediction in imbalanced medical data sets.BMC medical informatics and decision making · 2026Article
- Survival parametric modeling for patients with heart failure based on Kernel learning.BMC medical research methodology · 2025Article
- BOO-ST and CBCEC: two novel hybrid machine learning methods aim to reduce the mortality of heart failure patients.Scientific reports · 2023Article
- Combining symbolic regression with the Cox proportional hazards model improves prediction of heart failure deaths.BMC medical informatics and decision making · 2022Article
- IoT Based Smart Monitoring of Patients' with Acute Heart Failure.Sensors (Basel, Switzerland) · 2022Article
- Machine learning can predict survival of patients with heart failure from serum creatinine and ejection fraction alone.BMC medical informatics and decision making · 2020Article
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4 authors.
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Abstract
objectivesThe objective of this study was to build and assess the performance of survival prediction models using the gender-specific informative risk factors for patients with left ventricular systolic dysfunction.
methodsA lasso approach was used to decide the informative predictors for building semi-parametric proportional hazards Cox model. Separate models were built for all patients [N = 299], male patients [Nmale = 194 (64.88%)], and female patients [Nfemale = 105 (35.12%)], to observe the risk factors associated with the individual's risk of death. The likelihood- ratio test was used to test the goodness of fit of the selected model, and the C-index was used to assess the predictive performance of the selected model(s) with respect to the overall model with all observed risk factors.
resultsThe survival prediction model for females is notably different from that for males. For males, smoking, diabetes, and anaemia, whereas for females, ejection fraction, sodium, and platelets count are non-informative with zero regression coefficients. The goodness of fit of the selected models with respect to the general model with all observed risk factors is tested using the likelihood-ratio test. The results are in favor of the selected models with p-values 0.51,0.61, and 0.70 for all patients, male patients, and female patients, respectively. The same values of C-index for the full model and the selected models for overall data, for males, and for females (0.72, 0.73, and 0.77 for overall data, male data, and female data, respectively) indicate that the selected models are as good as the corresponding overall models regarding their predictive performance.
conclusionThere is a substantial difference in the survival prediction models for heart failure (HF) of male and female patients in this study. More studies are needed in Pakistan for confirming this striking male-female difference regarding the potential risk factors to predict survival with heart failure.
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