Evidence map›Paper›PMID 30779686›Full record

ArticleHuman vaccines & immunotherapeutics2019

Pre-vaccination IgG screening for mumps is the most cost-effectiveness immunization strategy among Health Care Workers.

Luca Coppeta, Ottavia Balbi, Savino Baldi, Antonio Pietroiusti, Andrea Magrini

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

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  16. Rubella Immunity among Italian Female Healthcare Workers: A Serological Study.International journal of environmental research and public health · 2020
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  17. Cost-effectiveness of workplace vaccination against measles.Human vaccines & immunotherapeutics · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Luca Coppetaa Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy.
Ottavia Balbia Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy.
Savino Baldia Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy.
Antonio Pietroiustia Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy.
Andrea Magrinia Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Health Care Workers (HCWs) have an increased risk of contracting contagious disease, including mumps. In January 2017 the Italian National Vaccine Prevention Plan 2017-2019, recommended the administration of a dose of MMR vaccine (Measles-Mumps-Rubella) to the Health Care Workers (HCWs) that, working in a risky environment, did not carry out the complete vaccination cycle of MMR or that are seronegative for at least one of the three vaccine viruses. In October of the same year, the Advisory Committee on Immunization Practices (ACIP) recommended a third dose of a vaccine containing Mumps Virus for people previously vaccinated with 2 doses, belonging to a group or to a population at increased risk of acquire mumps in the event of an epidemic. We analyzed the clinical records and values of mumps-specific IgG antibodies of 3032 HCWs (mean age 32.80 ± 10.75 years), that underwent occupational health surveillance between January 1st 2017 and March 31th 2018. The HCWs were also screened for measles, rubella, mumps using serological methods. 13% (405) was seronegative for mumps, especially among HCWs between 18 and 36 years. We calculated the cost-effectiveness of two-doses and three-doses MMR vaccination. The cost of vaccination without screening was significantly more expensive (cost difference: 99 712 € and 184 996 €) both in case of two-dose and three-dose MMR vaccination respectively. Our study suggests that, in HCWs, the assessment of the mumps antibody titer before vaccination may be a useful complement to vaccination itself, because it is more accurate and cost-effective than direct immunization of unvaccinated subjects.

Indexed as

Health PersonnelAdolescentAdultAgedAntibodies, ViralCost-Benefit AnalysisFemaleHumansImmunization ScheduleImmunoglobulin GMaleMeaslesMeasles-Mumps-Rubella VaccineMiddle AgedMumpsRubellaAntibodies, ViralImmunoglobulin GMeasles-Mumps-Rubella Vaccinehealth care workersinfectionMumpsmumps vaccinationOccupational epidemiology

Identifiers

PMID30779686
PMCPMC6605818
OpenAlexW2916640929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.