ReviewCirculation2019
Sex Differences in Advanced Heart Failure Therapies.
Review in Circulation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Integrating sex and gender in studies of cardiac resynchronization therapy: a systematic review.ESC heart failure · 2022Pooled it
- Role of sex on the efficacy of pharmacological and non-pharmacological treatment of heart failure with reduced ejection fraction: A systematic review.Frontiers in cardiovascular medicine · 2022Pooled it
- Transthyretin Amyloid Cardiomyopathy in Women: Epidemiology, Diagnostic Delay, and Clinical Implications.Cardiology and therapy · 2026Review
- Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review).International journal of molecular medicine · 2026Review
- Exploring Sex and Clinical Factors Associated with Long-Term Survival After Implantable Cardioverter-Defibrillator Implantation: A 10-Year Cohort Study.Journal of clinical medicine · 2026Article
- Sex differences in patients with advanced heart failure: an analysis of the HELP-HF registry.ESC heart failure · 2026Article
- Exclusive research is bad science: the epidemiologic argument for diversity, equity, and inclusion in research.International journal of epidemiology · 2026Article
- Pacemaker therapy through a sex-specific lens: a narrative review of clinical and procedural disparities.Frontiers in cardiovascular medicine · 2026Review
- Are There Gender Differences in the Benefits of Multidisciplinary Care in Patients with Heart Failure? Results from the UMIPIC Program.Journal of clinical medicine · 2025Article
- Impella 5.5 use in women: A multicenter study.JHLT open · 2025Article
- Does race influence health-related quality of life outcomes in older patients who undergo advanced cardiac surgical therapies?JHLT open · 2025Article
- Race, Genetics, and Social Determinants of Health in Transthyretin Cardiac Amyloidosis: A Literature Review and Call to Action.Current cardiology reports · 2025Review
- Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device.iScience · 2025Article
- Non-Medical Characteristics Affect Referral for Advanced Heart Failure Services: a Retrospective Review.Journal of racial and ethnic health disparities · 2025Article
- An Update on the Role of Renal Artery Denervation in the Treatment of Hypertension.Current treatment options in cardiovascular medicine · 2025Article
- Cost-effectiveness analysis of bridge-to-transplantation temporary mechanical circulatory support versus non-bridged heart transplantation.Frontiers in public health · 2025Article
- Specificities of Myocardial Infarction and Heart Failure in Women.Journal of clinical medicine · 2024Review
- Impact of biological sex on heart transplant patients admitted to cardiac rehabilitation: A 10-year retrospective cohort study.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Sex and Gender-related Disparities in Clinical Characteristics and Outcomes in Heart Transplantation.Current heart failure reports · 2024Review
- Advanced Heart Failure Characteristics and Outcomes in Women and Men.Journal of the American Heart Association · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
This in-depth review of sex differences in advanced heart failure therapy summarizes the existing literature on implantable cardioverter defibrillators, biventricular pacemakers, mechanical circulatory support, and transplantation with a focus on utilization, efficacy/clinical effectiveness, adverse events, and controversies. One will learn about the controversies regarding efficacy/clinical effectiveness of implantable cardioverter defibrillators and understand why these devices should be implanted in women even if there are sex differences in appropriate shocks. Individuals will learn about the sex differences with biventricular pacemakers with respect to ventricular remodeling and reduction in heart failure hospitalizations/mortality, as well as, possible mechanisms. We will demonstrate sex differences in heart transplantation and waitlist survival. Despite similar survival for women and men with left ventricular assist devices, there are sex differences in adverse events. These devices do successfully bridge women and men to transplant, yet women are less likely than men to have a left ventricular assist at time of listing and time of transplantation. Finally, one will learn about the concerns regarding poor outcome for men who receive female donor hearts and discover this may not be due to sex, but rather size. More research is needed to better understand sex differences and further improve advanced heart failure therapy for both women and men.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.