Evidence map›Paper›PMID 30779607›Full record

ArticleHealth security2019

The Special Pathogens Research Network: Enabling Research Readiness.

Colleen S Kraft, Mark G Kortepeter, Bruce Gordon, Lauren M Sauer, Erica S Shenoy, Daniel P Eiras, LuAnn Larson, Jennifer A Garland, Aneesh K Mehta, Kevin Barrett and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Health security, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Colleen S KraftColleen S. Kraft, MD, MSc, is Associate Professor, Department of Pathology and Laboratory Medicine, and Associate Professor, Division of Infectious Diseases, Emory University, Atlanta, GA.
Mark G KortepeterMark G. Kortepeter, MD, MPH, is Professor of Epidemiology, Department of Epidemiology, University of Nebraska Medical Center, Omaha, NE.
Bruce GordonBruce Gordon, MD, is Professor, Division of Pediatric Hematology/Oncology, University of Nebraska Medical Center, Omaha, NE.
Lauren M SauerLauren M. Sauer, MS, is Assistant Professor, Director of Research, Johns Hopkins Biocontainment Unit, Department of Emergency Medicine, Johns Hopkins Medicine, Baltimore, MD.
Erica S ShenoyErica S. Shenoy, MD, PhD, is Assistant Professor of Medicine, Harvard Medical School, and Associate Chief, Infection Control Unit, Massachusetts General Hospital, Boston, MA.
Daniel P EirasDaniel P. Eiras, MD, MPH, is Associate Hospital Epidemiologist, Infection Prevention and Control Department, NYU Langone Medical Center, New York, NY.
LuAnn LarsonLuAnn Larson, RN, BSN, is Director of Clinical Operations Nurse Manager, Clinical Research Biostatistics, University of Nebraska Medical Center, Omaha, NE.
Jennifer A GarlandJennifer A. Garland, RN, PhD, is Special Pathogens Program Coordinator, Cedars-Sinai Medical Center, Los Angeles, CA.
Aneesh K MehtaAneesh K. Mehta, MD, is an Assistant Professor, Division of Infectious Diseases, Emory University, Atlanta, GA.
Kevin BarrettKevin Barrett, RN, is a Nurse Specialist, NIH Clinical Center, the National Institute of Allergy and Infectious Diseases, Bethesda, MD.
Connie S PriceConnie S. Price, MD, is Professor of Medicine, University of Colorado School of Medicine, and Chief Medical Officer, Denver Health and Hospital, Denver, CO.
Caroline CroyleCaroline Croyle, MPH, is an Infection Prevention Specialist, Denver Health and Hospital, Denver, CO.
Lauren R West
Brooke NorenBrooke Noren, RN, is Research Nurse Coordinator, University of Minnesota Medical Center, Minneapolis, MN.
Susan KlineSusan Kline, MD, MPH, is Associate Professor of Medicine, Division of Infectious Diseases and International Medicine, University of Minnesota, Minneapolis, MN.
Christa ArguinchonaChrista Arguinchona is Assistant Nurse Manager, Providence Health and Services, Spokane, WA.
Henry ArguinchonaHenry Arguinchona, MD, is an infectious disease specialist, Providence Health and Services, Spokane, WA.
Jonathan D GreinJonathan D. Grein, MD, is Director, Hospital Epidemiology, Cedars-Sinai Medical Center, Los Angeles, CA.
Chad ConnallyChad Connally, RN, MSN, is Biocontainment and Emergency Management Program Manager, University of Texas Medical Branch, Galveston, TX.
Susan McLellanSusan McLellan, MD, MPH, is Professor and Biocontainment Unit Director, University of Texas Medical Branch, Galveston, TX.
George F RisiGeorge F. Risi, MD, MSc, is Senior Medical Adviser, Tunnell Government Services, a contractor, BARDA, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington, DC.
Timothy M UyekiTimothy M. Uyeki, MD, MPH, is Chief Medical Officer, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA.
Richard T DaveyRichard T. Davey, Jr., MD, is Chief, Clinical Research Section, the National Institute of Allergy and Infectious Diseases, Bethesda, MD.
Jo Ellen SchweinleJo Ellen Schweinle, MD, is a Supervisory Health Scientist, BARDA, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington, DC.
Michelle M SchwedhelmMichelle M. Schwedhelm, MSN, is Executive Director, Emergency Management & Biopreparedness, University of Nebraska Medical Center, Omaha, NE.
Melissa HarveyMelissa Cole Harvey, MSPH, is Director, Division of National Healthcare Preparedness Programs, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington, DC.
Richard C HuntRichard C. Hunt, MD, MS, is Senior Medical Advisor, Division of National Healthcare Preparedness Programs, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services, Washington, DC.
Christopher J KratochvilChristopher J. Kratochvil, MD, is Associate Vice Chancellor for Clinical Research, the University of Nebraska Medical Center, Omaha, NE.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

The 2013-2016 epidemic of Ebola virus disease (EVD) that originated in West Africa underscored many of the challenges to conducting clinical research during an ongoing infectious disease epidemic, both in the most affected countries of Guinea, Liberia, and Sierra Leone, as well as in the United States and Europe, where a total of 27 patients with EVD received care in biocontainment units. The Special Pathogens Research Network (SPRN) was established in the United States in November 2016 to provide an organizational structure to leverage the expertise of the 10 Regional Ebola and Other Special Pathogen Treatment Centers (RESPTCs); it was intended to develop and support infrastructure to improve readiness to conduct clinical research in the United States. The network enables the rapid activation and coordination of clinical research in the event of an epidemic and facilitates opportunities for multicenter research when the RESPTCs are actively caring for patients requiring a biocontainment unit. Here we provide an overview of opportunities identified in the clinical research infrastructure during the West Africa EVD epidemic and the SPRN activities to meet the ongoing challenges in the context of Ebola virus and other special pathogens.

Indexed as

Medical CountermeasuresAfricaBiomedical ResearchContainment of BiohazardsEbolavirusEmergency Medical ServicesEpidemicsEuropeHemorrhagic Fever, EbolaHumansInfection ControlTertiary Care CentersUnited StatesClinical researchEbola virus diseaseInvestigational therapeuticsSpecial pathogens

Identifiers

PMID30779607
PMCPMC6669031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.