Evidence map›Paper›PMID 30779478›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019

Osteogenic ability of rat bone marrow concentrate is at least as efficacious as mesenchymal stem cells in vitro.

Yusuke Kohno, Tzuhua Lin, Jukka Pajarinen, Monica Romero-Lopez, Masahiro Maruyama, Jhih-Fong Huang, Karthik Nathan, Zhenyu Yao, Stuart B Goodman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yusuke KohnoDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.ORCID 0000-0003-1821-4560
Tzuhua LinDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Jukka PajarinenDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Monica Romero-LopezDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Masahiro MaruyamaDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Jhih-Fong HuangDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Karthik NathanDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Zhenyu YaoDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Stuart B GoodmanDepartment of Orthopaedic Surgery, Stanford University, Stanford, California.
Stanford University · US

Funding

Wear Particle Disease and NF-kappa B SignalingR01AR063717 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2012 to 2021
$3.5M
Tissue Chip Modeling of Synovial Joint Pathologies: Effects of Inflammation and Adipose-Mediated Diabetic ComplicationsUG3TR002136 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TUAN, ROCKY S · 2017 to 2018
$2.5M
Tissue Engineering Approaches for Improved Treatment of Early Stage Osteonecrosis of the HipR01AR072613 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B, YANG, YUNZHI · 2018 to 2022
$2.2M
Customized MSCs to Enhance Healing of Bone DefectsR01AR073145 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2018 to 2021
$1.4M
Ellenburg Chair in Surgery at Stanford UniversityNCATS NIH HHS 1UG3TR002136-01NCATS NIH HHS UG3 TR002136NIAMS NIH HHS R01 AR063717NIAMS NIH HHS R01 AR072613NIAMS NIH HHS R01 AR073145NIH HHS R01AR063717-06NIH HHS R01AR073145
6 · The paper itself

Abstract

Cell therapy using bone marrow concentrate (BMC) or purified and expanded mesenchymal stem cells (MSCs) has been shown to have a promising osteogenic capacity. However, few studies have directly compared their relative osteogenic ability. The aim of this study was to compare the osteogenic ability of BMC isolated by density gradient centrifugation with bone marrow-derived MSCs in vitro using the cells of 3-month-old Sprague-Dawley rats. The isolated cells were seeded onto 24-well plates (1 × 10

Indexed as

AnimalsAntigens, DifferentiationBone Marrow CellsDexamethasoneMaleMesenchymal Stem CellsOsteogenesisRatsRats, Sprague-DawleyAntigens, DifferentiationDexamethasonebone marrow concentratebone regenerationcell therapymesenchymal stem cellosteogenesis

Identifiers

PMID30779478
PMCPMC6699939
OpenAlexW2915310589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.