ArticleJournal of clinical laboratory analysis2019
Distribution of serum neuron-specific enolase and the establishment of a population reference interval in healthy adults.
Article in Journal of clinical laboratory analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The Impact of Intravenous Agitated Saline Contrast Echocardiography on Subclinical Neuronal Injury Determined By Neuron-Specific Enolase.Anatolian journal of cardiology · 2026Article
- Establishing reference intervals for serum glutathione reductase in healthy adults.Archives of medical science : AMS · 2025Article
- Establishing Neuron-Specific Enolase Reference Intervals: A Comparative Analysis of Partitioned Approach- and Gender-Based Continuous Age- and Season-Related Models.Diagnostics (Basel, Switzerland) · 2024Article
- Advances and Challenges in Nanomaterial-Based Electrochemical Immunosensors for Small Cell Lung Cancer Biomarker Neuron-Specific Enolase.ACS omega · 2024Review
- The automated processing algorithm to correct the test result of serum neuron-specific enolase affected by specimen hemolysis.Journal of clinical laboratory analysis · 2021Article
- Age-stratified and gender-specific reference intervals of six tumor markers panel of lung cancer: A geographic-based multicenter study in China.Journal of clinical laboratory analysis · 2021Article
- Distribution of urinary N-acetyl-beta-D-glucosaminidase and the establishment of reference intervals in healthy adults.Journal of clinical laboratory analysis · 2021Article
- Combining serum calcitonin, carcinoembryonic antigen, and neuron-specific enolase to predict lateral lymph node metastasis in medullary thyroid carcinoma.Journal of clinical laboratory analysis · 2020Article
- Distribution of serum amyloid A and establishment of reference intervals in healthy adults.Journal of clinical laboratory analysis · 2020Article
- Correction of serum NSE reference intervals includes the unidentified hemolysis sample: 1-year data analysis from healthcare individuals.Journal of clinical laboratory analysis · 2019Article
- Distribution of serum neuron-specific enolase and the establishment of a population reference interval in healthy adults.Journal of clinical laboratory analysis · 2019Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundNeuron-specific enolase (NSE) is an important tumor marker in the serum of patients with lung cancer. Elevated serum NSE levels are also associated with many other diseases. However, there is no unified population reference interval for serum NSE. This study aimed to investigate the distribution of serum NSE in healthy Chinese adults aged 20-79 years and to establish its reference interval in Chinese population.
methodsA total of 10 575 healthy subjects were in line with the requirements of this study. The concentration of serum NSE was detected by a fully automated Cobas e602 analyzer with matching reagents. The population reference interval for serum NSE was established using the unilateral 95th percentile (P
resultsThe distributions of serum NSE were not significantly different between males and females (P > 0.05) and also did not differ by age (P > 0.05). Therefore, the population reference interval for serum NSE was established as upper limit 25.4 ng/mL (90% confidence interval: 24.5-26.2 ng/mL).
conclusionsWe established the first population reference interval for serum NSE in a large healthy Chinese adult cohort, which was higher than that recommended by Roche Diagnostics GmbH. This new reference interval is more practical and applicable in Chinese adults.
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