Evidence map›Paper›PMID 30779330›Full record

ArticleCPT: pharmacometrics & systems pharmacology2019

Misidentification Subtype of Alzheimer's Disease Psychosis Predicts a Faster Cognitive Decline.

Fabrizia D'Antonio, Suzanne Reeves, Yucheng Sheng, Emma McLachlan, Carlo de Lena, Robert Howard, Julie Bertrand

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Fabrizia D'AntonioDivision of Psychiatry, University College London, London, UK.
Suzanne ReevesDivision of Psychiatry, University College London, London, UK.
Yucheng ShengDepartment of Pharmaceutics, School of Pharmacy, University College London, London, UK.
Emma McLachlanDepartment of Old Age Psychiatry, King's College London, London, UK.
Carlo de LenaDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Robert HowardDivision of Psychiatry, University College London, London, UK.
Julie BertrandUMR 1137 Infection, Antimicrobials, Modelling, Evolution (IAME) French Institute for Medical Research (INSERM), University Paris, Paris, France.
University College London · GBEcologie & Evolution · FRKing's College School · GBSapienza University of Rome · IT

Funding

Department of Health NIHR/CS/010/019
6 · The paper itself

Abstract

The presence of psychosis is associated with a more rapid decline in Alzheimer's disease (AD), but the impact of paranoid (persecutory delusions) and misidentification (misperceptions and/or hallucinations) subtypes of psychosis on the speed of decline in AD is still unclear. We analyzed data on Alzheimer's Disease Neuroimaging Initiative 2 participants with late mild cognitive impairment or AD, and we described individual trajectories of Alzheimer's Disease Assessment Scale-Cognitive Subscale scores using a semimechanistic logistic model with a mixed effects-based approach, which accounted for dropout and adjusted for baseline Mini Mental State Examination scores. The covariate model included psychosis subtypes, age, gender, education, medications, and Apolipoprotein E epsilon 4 (Apo-e ε4 genotype). We found that the Alzheimer's Disease Assessment Scale-Cognitive Subscale rate of increase was doubled in misidentification (β

Indexed as

AgedAged, 80 and overAlzheimer DiseaseApolipoproteins ECognitive DysfunctionFemaleGenotypeHumansLogistic ModelsLongitudinal StudiesMaleMental Status and Dementia TestsMulticenter Studies as TopicPsychotic DisordersApoE protein, humanApolipoproteins E

Identifiers

PMID30779330
PMCPMC6533361
OpenAlexW2916566999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.