ArticleHuman brain mapping2019
White matter tracts lesions and decline of verbal fluency after deep brain stimulation in Parkinson's disease.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Speech, voice, and language outcomes following deep brain stimulation: A systematic review.PloS one · 2024Pooled it
- The Frontal Aslant Tract: A Systematic Review for Neurosurgical Applications.Frontiers in neurology · 2021Pooled it
- Effects of Deep Brain Stimulation in the Subthalamic Nucleus on Neurocognitive Function in Patients With Parkinson's Disease Compared With Medical Therapy: A Meta-Analysis.Frontiers in neurology · 2021Pooled it
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Leukoaraiosis does not impact motor outcomes in Parkinson's patients post deep brain stimulation.Clinical parkinsonism & related disorders · 2025Article
- Altered Cognitive Networks Connectivity in Parkinson's Disease During the Microlesion Period After Deep Brain Stimulation.CNS neuroscience & therapeutics · 2024Article
- Subthalamic nucleus-language network connectivity predicts dopaminergic modulation of speech function in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits.Brain and behavior · 2024Review
- Cognitive aspects of motor control deteriorate while off treatment following subthalamic nucleus deep brain stimulation surgery in Parkinson's disease.Frontiers in neurology · 2024Article
- Insertional effect following electrode implantation: an underreported but important phenomenon.Brain communications · 2024Review
- Differential cognitive effects of unilateral left and right subthalamic nucleus deep brain stimulation for Parkinson disease.medRxiv : the preprint server for health sciences · 2023Article
- Neural correlates of verbal fluency revealed by longitudinal T1, T2 and FLAIR imaging in stroke.NeuroImage. Clinical · 2023Article
- A narrative review of the anatomy and function of the white matter tracts in language production and comprehension.Frontiers in human neuroscience · 2023Review
- Neuronal activity and remyelination: new insights into the molecular mechanisms and therapeutic advancements.Frontiers in cell and developmental biology · 2023Review
- Attenuated brain white matter functional network interactions in Parkinson's disease.Human brain mapping · 2022Article
- Optimized Deep Brain Stimulation Surgery to Avoid Vascular Damage: A Single-Center Retrospective Analysis of Path Planning for Various Deep Targets by MRI Image Fusion.Brain sciences · 2022Article
- Altered Interhemispheric Functional Connectivity Associated With Early Verbal Fluency Decline After Deep Brain Stimulation in Parkinson's Disease.Frontiers in aging neuroscience · 2022Article
- Deep brain stimulation effects on verbal fluency dissociated by target and active contact location.Annals of clinical and translational neurology · 2021Article
- Altered Spontaneous Neural Activity and Functional Connectivity in Parkinson's Disease With Subthalamic Microlesion.Frontiers in neuroscience · 2021Article
- Altered Regional Homogeneity and Functional Connectivity during Microlesion Period after Deep Brain Stimulation in Parkinson's Disease.Parkinson's disease · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Decline of verbal fluency (VF) performance is one of the most systematically reported neuropsychological adverse effects after subthalamic nucleus deep brain stimulation (STN-DBS). It has been suggested that this worsening of VF may be related to a microlesion due to the electrode trajectories. We describe the disruption of surrounding white matter tracts following electrode implantation in Parkinson's disease (PD) patients with STN-DBS and assess whether damage of fiber pathways is associated with VF impairment after surgery. We retrospectively analyzed 48 PD patients undergoing bilateral STN DBS. The lesion mask along the electrode trajectory transformed into the MNI 152 coordinate system, was compared with white matter tract atlas in Tractotron software, which provides a probability and proportion of fibers disconnection. Combining tract- and atlas-based analysis reveals that the trajectory of the electrodes intersected successively with the frontal aslant tract, anterior segment of arcuate tract, the long segment of arcuate tract, the inferior longitudinal fasciculus, the superior longitudinal fasciculus, the anterior thalamic radiation, and the fronto striatal tract. We found no association between the proportion fiber disconnection and the severity of VF impairment 6 months after surgery. Our findings demonstrated that microstructural injury associated with electrode trajectories involved white matter bundles implicated in VF networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.