Evidence map›Paper›PMID 30779214›Full record

ArticleJournal of veterinary internal medicine2019

The association of indoxyl sulfate with fibroblast growth factor-23 in cats with chronic kidney disease.

Yu-Lun Liao, Chi-Chung Chou, Ya-Jane Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

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  3. Supplementation withThe veterinary quarterly · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Yu-Lun LiaoDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan.
Chi-Chung ChouDepartment of Veterinary Medicine, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan.
Ya-Jane LeeInstitute of Veterinary Clinical Science, School of Veterinary Medicine, College of Bio-Resources and Agriculture, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-4884-7019
National Chung Hsing University · TWNational Taiwan University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 107-2313-B-002-053
6 · The paper itself

Abstract

backgroundIndoxyl sulfate (IS) has been reported not only to increase with the severity of impaired renal function, but also possibly to be a factor associated with bone abnormalities linked to fibroblast growth factor-23 (FGF-23) in humans with chronic kidney disease (CKD). It is not yet known whether this correlation between IS and FGF-23 holds true for cats with CKD. HYPOTHESIS: Accumulation of IS is related to FGF-23 secretion in cats with CKD. ANIMALS: Twenty clinically healthy cats and 73 cats with CKD cases were evaluated retrospectively.

methodsThe concentrations of IS and FGF-23 in plasma were determined by high-performance liquid chromatography and ELISA, respectively. Progression was defined as an increment of 0.5 mg/dL of serum creatinine concentration within 3 months.

resultsPlasma IS and FGF-23 concentrations were significantly increased concurrently with decreasing renal function. Higher concentration of FGF-23 was significantly associated with higher concentration of IS after adjusting for various confounding factors including creatinine and phosphate. Furthermore, the correlation between IS and phosphate was higher than that between FGF-23 and phosphate. When the renal progression group was compared with the non-progression group, both IS and FGF-23 were found to be significantly increased (P < .05). In addition, the area under receiver operator curve of the combination of IS and FGF-23 predicted renal progression at a level >0.9. CONCLUSIONS AND CLINICAL IMPORTANCE: Both FGF-23 and IS are associated with phosphate metabolism and CKD progression.

Indexed as

AnimalsCase-Control StudiesCat DiseasesCatsChromatography, High Pressure LiquidDisease ProgressionEnzyme-Linked Immunosorbent AssayFemaleFibroblast Growth Factor-23Fibroblast Growth FactorsIndicanMaleRenal Insufficiency, ChronicRetrospective StudiesSeverity of Illness IndexFGF23 protein, humanFibroblast Growth Factor-23Fibroblast Growth FactorsIndicanazotemiafeline renal diseasesphosphate regulatorprogressionuremic toxin

Identifiers

PMID30779214
PMCPMC6430881
OpenAlexW2916769565

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.