ArticleTransfusion2019
Association of blood donation with iron deficiency among adolescent and adult females in the United States: a nationally representative study.
Article in Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Evaluating utility of routine ferritin testing in blood donors: A hospital-based blood donor centre experience.Transfusion medicine (Oxford, England) · 2024Article
- Next generation sequencing to identify iron status and individualise blood donors' experience.Blood transfusion = Trasfusione del sangue · 2023Article
- Development and validation of a prediction model for iron status in a large U.S. cohort of women.Scientific reports · 2023Article
- Associations of donor, component, and recipient factors on hemoglobin increments following red blood cell transfusion in very low birth weight infants.Transfusion · 2023Article
- A reference interval study of ferritin and transferrin levels in donors from two blood centers.Experimental and therapeutic medicine · 2023Article
- Eligibility Considerations for Female Whole Blood Donors: Hemoglobin Levels and Iron Status in a Nationally Representative Population.Transfusion medicine reviews · 2023Article
- Machine learning-based prediction of fainting during blood donations using donor properties and weather data as features.BMC medical informatics and decision making · 2022Article
- Iron Deficiency and Blood Donation: Links, Risks and Management.Journal of blood medicine · 2022Review
- Supplemental findings of the 2017 National Blood Collection and Utilization Survey.Transfusion · 2020Article
- Factors associated with anaemia and iron deficiency among women of reproductive age in Northeast Thailand: a cross-sectional study.BMC public health · 2020Article
- Sociodemographic and behavioral characteristics associated with blood donation in the United States: a population-based study.Transfusion · 2019Article
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11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBlood donation results in a loss of iron stores, which is particularly concerning for young female blood donors. This study examines the association of blood donation and iron deficiency among adolescent and adult females in the United States. STUDY DESIGN AND
methodsA cross-sectional analysis was performed using data from the 1999-2010 National Health and Nutrition Examination Survey (NHANES). Females who reported their blood donation history in the preceding year and had serum ferritin (SF) measurements were included. Analyses were weighted and stratified by adolescents (16-19 years; n = 2419) and adults (20-49 years; n = 7228). Adjusted prevalence ratios (aPRs) were estimated by multivariable Poisson regression. Standard errors were estimated by Taylor series linearization.
resultsGeometric mean SF levels (ng/mL) were lower in blood donors compared to nondonors among adolescents (21.2 vs. 31.4; p < 0.001) and among adults (26.2 vs. 43.7; p < 0.001). The prevalence of absent iron stores (SF < 12 ng/mL) was higher in blood donors compared to nondonors among adolescents (22.6% vs. 12.2%; aPR = 2.03 [95% confidence interval (CI) = 1.45-2.85]) and among adults (18.3% vs. 9.8%; aPR = 2.06 [95% CI = 1.48-2.88]). Additionally, the prevalence of iron deficiency anemia (SF < 26 ng/mL and hemoglobin < 12.0 g/dL) was also higher in blood donors compared to nondonors among adolescents (9.5% vs. 6.1%; aPR = 2.10 [95% CI = 1.13-3.90]) and among adults (7.9% vs. 6.1%; aPR = 1.74 [95% CI = 1.06-2.85]). Similar results were observed in a sensitivity analysis restricted to adolescents aged 16 to 18 years.
conclusionsBlood donation is associated with iron deficiency among adolescent and adult females in the United States. These national data call for further development and implementation of blood donation practices aimed toward mitigating iron deficiency.
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