Evidence map›Paper›PMID 30778924›Full record

ArticleMolecular biology reports2019

Sexual dimorphism in the expression of GKN2 and FOXA2 genes in the human stomach.

Reza Mohammadi, Zahra Mohammadi, Reza Abedi, Fatemeh Chireh, Abdolreza Balali, Parisa Mohamadynejad, Sadegh Shirian, Mehdi Moghanibashi

Abstract read
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In one paragraph

Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Women with chronic follicular gastritis positive for Helicobacter pylori express lower levels of GKN1.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Reza MohammadiDepartment of Biology, Faculy of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.ORCID https://orcid.org/0000-0002-7886-8390
Zahra MohammadiDepartment of Biology, Faculy of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.ORCID https://orcid.org/0000-0003-3880-0030
Reza AbediDepartment of Biology, Faculy of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.ORCID https://orcid.org/0000-0003-2645-0707
Fatemeh ChirehDepartment of Biology, Faculy of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.ORCID https://orcid.org/0000-0001-7636-3463
Abdolreza BalaliImam Ali Hospital, Farokhshar, Shahrekord, Iran.ORCID https://orcid.org/0000-0001-5862-5108
Parisa MohamadynejadDepartment of Biology, Faculy of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.ORCID https://orcid.org/0000-0002-1343-9069
Sadegh ShirianDepartment of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
Mehdi MoghanibashiDepartment of Genetics, School of Medicine, Kazerun Branch, Islamic Azad University, P.O. Box: 73135-168, Kazerun, Iran. mehdimoghani@yahoo.com.ORCID http://orcid.org/0000-0003-0023-9399
Islamic Azad University of Shahrekord · IRShahrekord University · IRIslamic Azad University Kazeron · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A large proportion of the transcriptome is sex biased in a wide range of taxa. Sexually dimorphic genes expression is highly tissue-dependent. Although gastric cancer exhibits sex bias to some extent, sexually dimorphic gene expression in the stomach is yet to be fully understood. The aim of the present study was to compare the expression levels of 12 genes in the gastric tissue between age-matched healthy men and women of different age groups. A total of 70 human antrum gastric tissue samples were obtained by endoscopy. The difference in expression levels of the 12 intended genes between two genders was investigated using quantitative Real-Time PCR, following total RNA extraction. The results indicated that the expression levels of both the GKN2 (7.2-fold, p < 0.001) and FOXA2 (3.7-fold, p = 0.003) were significantly higher in men compared to those in women. In addition, FOXA1 gene expression was age-dependent only in women. Interestingly, the expression level of FOXA1 was significantly higher in premenopausal women compared to postmenopausal women (2.53-fold, p = 0.016). The expression levels of some of the investigated genes in this study were sex-dependent in the stomach. This sexual dimorphism in gene expression might influence the differential susceptibility to the gastric cancer between the sexes.

Indexed as

AdultAgedAge FactorsCarrier ProteinsFemaleGene ExpressionGene Expression ProfilingHepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaHumansMaleMiddle AgedSex CharacteristicsStomachStomach NeoplasmsTranscriptomeCarrier ProteinsFOXA1 protein, humanFOXA2 protein, humanGKN2 protein, humanHepatocyte Nuclear Factor 3-alphaHepatocyte Nuclear Factor 3-betaFOXA1FOXA2Gastric cancerGKN2Sexual dimorphism

Identifiers

PMID30778924
OpenAlexW2915140009

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.