ArticleJournal of nephrology2019
A cardiac magnetic resonance imaging study of long-term and incident hemodialysis patients.
Article in Journal of nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Review
- Value of native T1 mapping in the prediction of major adverse cardiovascular events in hemodialysis patients.European radiology · 2022Article
- Associations of B-type natriuretic peptide (BNP) and dialysis vintage with CMRI-derived cardiac indices in stable hemodialysis patients with a preserved left ventricular ejection fraction.The international journal of cardiovascular imaging · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cardiovascular morphology and function in long-term survivors of hemodialysis are not well described.
methodsSingle-center cross-sectional study nested within a prospective cohort study of 15 long-term (> 7.5 years) and 15 matched incident (< 6 months) hemodialysis patients with 15 external matched controls. Evaluations included heart structure, function and fibrosis (myocardial longitudinal relaxation time, native T1), and aortic dimensions and elasticity, using cardiovascular magnetic resonance (CMR). Coronary artery calcification (CAC) scores were evaluated from computed tomography (CT).
resultsIncident hemodialysis patients had significantly increased left ventricular mass, greater aortic dimensions and reduced aortic distensibility compared to long-term survivors, whereas the CAC score was significantly higher in long-term than incident patients, median (95% CI) 1127 (10-3861) vs 14 (0-268). Both incident and long-term hemodialysis groups had significantly higher native T1 values compared to controls, mean (95% CI) 1300 ms (1273-1326), 1274 ms (1243-1305) versus 1224 ms (1202-1246), respectively, suggesting interstitial fibrosis or edema. Compared to controls, both hemodialysis groups also had significantly lower left ventricular ejection fraction: 48.7% (43.6-53.9), 54.0% (48.3-59.7) versus 62.2% (58.0-66.4) and longitudinal strain: 14.0% (11.7-16.2), 15.2% (12.7-17.7) versus 19.6% (17.8-21.5).
conclusionsIncident hemodialysis patients had larger left ventricular mass and unfavorable aortic structure and function compared to long-term survivors, despite a lower CAC burden. Long-term survivors, despite normal ventricular mass and volumes, had signs of fibrosis or edema, given their significantly increased native T1 values.
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