Evidence map›Paper›PMID 30778878›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019

Italian recommendations for the diagnosis and treatment of myasthenia gravis.

Amelia Evoli, Giovanni Antonini, Carlo Antozzi, Antonio DiMuzio, Francesco Habetswallner, Cesare Iani, Maurizio Inghilleri, Rocco Liguori, Renato Mantegazza, Roberto Massa and 3 more

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The associations of HLA-DRB1 gene polymorphisms with late-onset myasthenia gravis: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Pooled it
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Italian recommendations for the diagnosis and treatment of myasthenia gravis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Observational
  14. Article
  15. Diaphragm ultrasound and neostigmine test as complementary tools in the diagnostic assessment of myasthenia gravis: insights from a clinical case.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Comorbidity in myasthenia gravis: multicentric, hospital-based, and controlled study of 178 Italian patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 11 institutions in 1 country.

Amelia EvoliInstitute of Neurology, Fondazione Policlinico "A. Gemelli" IRCCS, Università Cattolica del S. Cuore, Largo A. Gemelli 8, 00168, Rome, Italy. amelia.evoli@unicatt.it.ORCID http://orcid.org/0000-0003-0282-8787
Giovanni AntoniniDepartment of Neurosciences, Mental Health and Sensory Organs NESMOS, Università di Roma "La Sapienza", Rome, Italy.
Carlo AntozziDepartment of Neuroimmunology and Neuromuscular Diseases, Fondazione Istituto Neurologico C. Besta, Milan, Italy.
Antonio DiMuzioCentro Regionale Malattie Neuromuscolari, Ospedale Clinicizzato "SS Annunziata", Chieti, Italy.
Francesco HabetswallnerUOC Neurofisiopatologia AORN Cardarelli, Naples, Italy.
Cesare IaniNeurology Unit, Sant'Eugenio Hospital, Rome, Italy.
Maurizio InghilleriCentro Malattie Rare Neuromuscolari, Dipartimento di Neuroscienze Umane, Università di Roma "La Sapienza", Rome, Italy.
Rocco LiguoriDipartimento di Scienze Biomediche e Neuromotorie, Università di Bologna, Bologna, Italy.
Renato MantegazzaDepartment of Neuroimmunology and Neuromuscular Diseases, Fondazione Istituto Neurologico C. Besta, Milan, Italy.
Roberto MassaUnit Malattie Neuromuscolari, Dipartimento di Medicina dei Sistemi, Università di Roma "Tor Vergata", Rome, Italy.
Elena PegoraroDepartment of Neurosciences, University of Padova, Padova, Italy.
Roberta RicciardiDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Carmelo RodolicoUnit of Neurology and Neuromuscular Diseases, University of Messina, Messina, Italy.
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITSapienza University of Rome · ITIstituto delle Scienze Neurologiche di Bologna · ITOspedale Antonio Cardarelli · ITOspedale SS. Annunziata · ITSt. Eugenio Hospital · ITUniversità Cattolica del Sacro Cuore · ITUniversity of Messina · ITUniversity of Padua · ITUniversity of Pisa · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myasthenia gravis is a well-treatable disease, in which a prompt diagnosis and an adequate management can achieve satisfactory control of symptoms in the great majority of patients. Improved knowledge of the disease pathogenesis has led to recognition of patient subgroups, according to associated antibodies, age at onset and thymus pathology, and to a more personalized treatment. When myasthenia gravis is suspected on clinical grounds, diagnostic confirmation relies mainly on the detection of specific antibodies. Neurophysiological studies and, to a lesser extent, clinical response to cholinesterase inhibitors support the diagnosis in seronegative patients. In these cases, the differentiation from congenital myasthenia can be challenging. Treatment planning must consider weakness extension and severity, disease subtype, thymus pathology, together with patient characteristics and comorbidities. Since most subjects with myasthenia gravis require long-term immunosuppressive therapy, surveillance of expected and potential adverse events is critical. For patients refractory to conventional immunosuppression, the use of biologic agents is highly promising. These recommendations are addressed to non-experts on neuromuscular transmission disorders. The diagnostic procedures and therapeutic approaches hereafter described are largely accessible in Italy.

Indexed as

FemaleHumansItalyMaleMyasthenia GravisPractice Guidelines as TopicImmunosuppressive therapyMyasthenia gravisPlasma exchangeRituximabThymectomy

Identifiers

PMID30778878
OpenAlexW2916599842

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.