ArticleNeurology and therapy2019
Cerebrolysin as a New Treatment Option for Post-Stroke Spasticity: Patient and Physician Perspectives.
Article in Neurology and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 8 citations in OpenAlex.
- Add-on treatment with Cerebrolysin improves clinical symptoms in patients with ALS: results from a prospective, single-center, placebo-controlled, randomized, double-blind, phase II study.Journal of medicine and life · 2023Trial
- Neuroprotective Effects of Cerebrolysin in Moderate Traumatic Brain Injury with Nonoperative Lesions: A 6-Month Prospective Cohort Analysis.Asian journal of neurosurgery · 2026Article
- Pathophysiology and Management Strategies for Post-Stroke Spasticity: An Update Review.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRecent studies show that spasticity occurs in 20-30% of all stroke victims, especially in younger patients. Botulinum toxin is a very effective treatment; however, it is not reimbursed in the Ukraine, thus leaving patients untreated and unable to use the paralyzed limb. Finally, this might result in long-term disability with economic consequences and negative impact on the psychological state of patients. Therefore, alternative and affordable treatment options are of high interest. This case report describes the therapeutic experience with Cerebrolysin on post-stroke spasticity in a chronic stroke patient from both the investigator's and the patient's perspective.
methodsCerebrolysin was administered for 30 days at a daily dose of 10 mL by intramuscular (IM) injections into the spastic limb of a 56-year-old chronic stroke patient. Therapeutic effects were assessed by the Modified Ashworth Scale (MAS), the mRS, and manual muscle testing (MMT).
resultsAfter completing the treatment course with Cerebrolysin, spasticity-related outcome measures like MMT had improved by 70% and the MAS by 2 points. The patient reported a beneficial effect on mood and motivation.
conclusionIntramuscular treatment with Cerebrolysin of post-stroke spasticity was safe and effective in this patient. The experiences observed in this patient are in line with the findings of a larger cohort study treated in the same way in the Philippines.
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