Evidence map›Paper›PMID 30778834›Full record

ReviewJournal of molecular neuroscience : MN2019

Iron Deficiency, Cognitive Functions, and Neurobehavioral Disorders in Children.

Lyudmila Pivina, Yuliya Semenova, Monica Daniela Doşa, Marzhan Dauletyarova, Geir Bjørklund

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular neuroscience : MN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06662045 (Study on the Association Between Iron Deficiency Anemia and Neurobehavioral Development and Cognitive Function in Children Aged 6 to 24 Months), which is not on this map. Cited by 106 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 5 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06662045 recruitingnot on this mapstarted 2024, after this paper: background citation

Study on the Association Between Iron Deficiency Anemia and Neurobehavioral Development and Cognitive Function in Children Aged 6 to 24 Months

TypeobservationalSponsorPingshan District Maternal & Child Healthcare Hospital of ShenzhenRan2024 to 2027Enrolled1,000ConditionsIron-Deficiency Anemia, Neurobehavioral Manifestations, Growth Disorders, Nutritional Status
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 5 syntheses or guidelines pooled it, 253 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Daily oral iron supplementation during pregnancy.The Cochrane database of systematic reviews · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  9. Article
  10. Overlaps in mammalian iron and manganese homeostasis: recent advances.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Environmental Stressors, Anemia, and Depressive Symptoms in Pregnancy: Unpacking the Combined Risks.International journal of environmental research and public health · 2025
    Article
  19. Review
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Lyudmila PivinaSemey Medical University, Semey, Kazakhstan.
Yuliya SemenovaSemey Medical University, Semey, Kazakhstan.
Monica Daniela DoşaDepartment of Pharmacology, Faculty of Medicine, Ovidius University, Constanta, Romania.
Marzhan DauletyarovaAstana Medical University, Astana, Kazakhstan.
Geir BjørklundCouncil for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo i Rana, Norway. bjorklund@conem.org.ORCID http://orcid.org/0000-0003-2632-3935
Semey Medical University · KZAstana Medical University · KZOvidius University · ROThe Research Council of Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than 25% of the world's population is affected by anemia, of which more than 50% suffers from iron deficiency anemia (IDA). Children below 7 years of age are the population group that is most vulnerable to iron deficiency. Iron is an essential element in brain metabolism. Iron deficiency can cause changes in neurotransmitter homeostasis, decrease myelin production, impair synaptogenesis, and decline the function of the basal ganglia. Therefore, IDA adversely affects cognitive functions and psychomotor development. Research has shown that iron deficiency is a frequent comorbidity in attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder. Iron deficiency may also induce or exacerbate deficiency of other essential nutrients, which may have a negative impact on the developing brain and other organs in infants. Many nations of the world have programs to control IDA based on the use of iron supplementation, intake of fortified food and drinks, improved food safety, and monitoring of dietary diversity. Based on the current recommendations of the World Health Organization on cost-effectiveness (WHO-CHOICE), iron fortification and iron supplementation programs can be considered cost-effective or even highly cost-effective in most countries of the world to averting cognitive impairment.

Indexed as

Anemia, Iron-DeficiencyChildChild BehaviorCognitionCost of IllnessDevelopmental DisabilitiesHumansADHDAnemiaAutismChildrenCognitive functionIron deficiencyPsychomotor development

Identifiers

PMID30778834
OpenAlexW2917331737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.