Evidence map›Paper›PMID 30778712›Full record

ArticleCellular and molecular neurobiology2019

Increased Peripheral CD137 Expression in a Mouse Model of Permanent Focal Cerebral Ischemia.

Xiao-Qing Li, Yang-Yang Wang, Ting-Ting Yang, Yi-Ning Qian, He Yin, Shan-Shan Zhong, Rong A, Yang He, Bao-Lei Xu, Guang-Zhi Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Xiao-Qing LiDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yang-Yang WangDepartment of Neurology, Peking University People's Hospital, Beijing, 100044, China.
Ting-Ting YangDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Yi-Ning QianDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
He YinDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Shan-Shan ZhongDepartment of Neurology, Peking University People's Hospital, Beijing, 100044, China.
Rong ADepartment of Neurology, Peking University People's Hospital, Beijing, 100044, China.
Yang HeDepartment of Neurology, Peking University People's Hospital, Beijing, 100044, China.
Bao-Lei XuDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.
Guang-Zhi LiuDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. guangzhi2002@hotmail.com.ORCID http://orcid.org/0000-0001-8953-0005
Capital Medical University · CNPeking University · CN

Funding

National Natural Science Foundation of China NSF 81441040
6 · The paper itself

Abstract

Various studies demonstrate that CD137 (TNFRSF9, 4-1BB) promotes atherosclerosis and vascular inflammation in experimental models via interactions with the CD137 ligand (CD137L). However, the exact role of CD137 in ischemic stroke remains unclear. In this study, we analyzed dynamic changes of peripheral CD137 expression on T cells in a mouse model of cerebral ischemia-middle cerebral artery occlusion (MCAO), as well as alternation of neurological function, infarct size and cerebral inflammatory status after inhibition of the CD137/CD137L pathway using an anti-CD137L monoclonal antibody. MCAO mice showed elevated surface expression of CD137 on T cells in both peripheral blood and lymphoid tissues during early cerebral ischemia. Remarkably, blockade of the CD137/CD137L pathway reduced the post-ischemic brain damage. Our findings indicate that enhanced CD137 costimulation occurs in early cerebral ischemia and promotes T cell activation, which in turn upregulates inflammatory immune response and possibly exerting deleterious effects on cerebral ischemia.

Indexed as

4-1BB LigandAnimalsB-LymphocytesBrain IschemiaCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell MembraneCytokinesDisease Models, AnimalFemaleGene Expression RegulationInfarction, Middle Cerebral ArteryMatrix Metalloproteinase 9Mice, Inbred C57BLRNA, Messenger4-1BB LigandCytokinesMatrix Metalloproteinase 9RNA, MessengerCD137CD137LCerebral ischemiaMCAO

Identifiers

PMID30778712
PMCPMC11469804
OpenAlexW2917181271

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.