Evidence map›Paper›PMID 30778664›Full record

ArticleMammalian genome : official journal of the International Mammalian Genome Society2019

Genetic variation in thyroid folliculogenesis influences susceptibility to hypothyroidism-induced hearing impairment.

Amanda H Mortensen, Qing Fang, Michelle T Fleming, Thomas J Jones, Alexandre Z Daly, Kenneth R Johnson, Sally A Camper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Amanda H MortensenDepartment of Human Genetics, University of Michigan, 5705 Medical Science II, 1241 Catherine St., Ann Arbor, MI, 48109-5618, USA.
Qing FangDepartment of Human Genetics, University of Michigan, 5705 Medical Science II, 1241 Catherine St., Ann Arbor, MI, 48109-5618, USA.
Michelle T FlemingDepartment of Human Genetics, University of Michigan, 5705 Medical Science II, 1241 Catherine St., Ann Arbor, MI, 48109-5618, USA.
Thomas J JonesDepartment of Human Genetics, University of Michigan, 5705 Medical Science II, 1241 Catherine St., Ann Arbor, MI, 48109-5618, USA.
Alexandre Z DalyDepartment of Human Genetics, University of Michigan, 5705 Medical Science II, 1241 Catherine St., Ann Arbor, MI, 48109-5618, USA.
Kenneth R JohnsonThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 04609, USA.
Sally A CamperDepartment of Human Genetics, University of Michigan, 5705 Medical Science II, 1241 Catherine St., Ann Arbor, MI, 48109-5618, USA. scamper@umich.edu.
University of Michigan–Ann Arbor · USJackson Laboratory · US

Funding

University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
NHGRI NIH HHS T32 HG000040NIGMS NIH HHS T32 GM007544
6 · The paper itself

Abstract

Maternal and fetal sources of thyroid hormone are important for the development of many organ systems. Thyroid hormone deficiency causes variable intellectual disability and hearing impairment in mouse and man, but the basis for this variation is not clear. To explore this variation, we studied two thyroid hormone-deficient mouse mutants with mutations in pituitary-specific transcription factors, POU1F1 and PROP1, that render them unable to produce thyroid stimulating hormone. DW/J-Pou1f1

Indexed as

Disease SusceptibilityGenetic VariationAllelesAnimalsAnimals, NewbornBiomarkersBrain StemDisease Models, AnimalEar, MiddleHearing LossHypothyroidismImmunohistochemistryMiceMice, KnockoutMice, TransgenicMutationBiomarkersThyroid Hormones

Identifiers

PMID30778664
PMCPMC6939890
OpenAlexW2917511295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.