Evidence map›Paper›PMID 30778625›Full record

Trial reportEuropean journal of clinical pharmacology2019

Metamizole inhibits arachidonic acid-induced platelet aggregation after surgery and impairs the effect of aspirin in hospitalized patients.

C Pfrepper, S Deters, M Metze, R Siegemund, I Gockel, S Petros

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

C PfrepperDivision of Hemostaseology, University Hospital Leipzig, Liebigstr, 20, 04103, Leipzig, Germany. christian.pfrepper@medizin.uni-leipzig.ORCID http://orcid.org/0000-0002-0485-7402
S DetersDivision of Hemostaseology, University Hospital Leipzig, Liebigstr, 20, 04103, Leipzig, Germany.
M MetzeDepartment of Cardiology, University Hospital Leipzig, Leipzig, Germany.
R SiegemundDivision of Hemostaseology, University Hospital Leipzig, Liebigstr, 20, 04103, Leipzig, Germany.
I GockelDepartment of Visceral, Transplantation, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig, Germany.
S PetrosDivision of Hemostaseology, University Hospital Leipzig, Liebigstr, 20, 04103, Leipzig, Germany.
University Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe inhibitory effect of metamizole on platelet aggregation is known for several years, but most studies were conducted in healthy volunteers with contradictory results. Recent studies have shown an inhibitory effect of metamizole on acetylsalicylic acid (ASA)-induced platelet aggregation. We aimed to investigate the effect of metamizole on platelet aggregation after an elective surgery and the effect of metamizole on ASA-induced platelet aggregation in hospitalized patients.

methodsWe performed platelet aggregation analysis after induction with ADP, arachidonic acid (AA), epinephrine, and collagen in 37 patients prior to an elective visceral or thoracic surgery and on postoperative day (POD) 1 and POD 3 1-2 h and 5-6 h after metamizole. In another cohort of 10 hospitalized patients receiving the combination of metamizole and ASA for more than 7 days, AA-induced platelet aggregation was analyzed in the morning prior to the intake of both drugs.

resultsMetamizole induced a strong inhibitory effect on AA-induced platelet aggregation at all time points being detectable up to 41 h in some patients. Besides a less pronounced effect on collagen-induced platelet aggregation on POD 3 1-2 h after metamizole, all other inductors showed no effect. In 4 out of 10 hospitalized patients, no ASA-induced inhibition of platelet aggregation was detectable without correlation to sequence of administration.

conclusionsThe reason why some patients have a long-lasting inhibitory effect of metamizole on COX-induced platelet aggregation that might interfere with ASA should be investigated in a larger cohort of patients.

Indexed as

Arachidonic AcidAdultAgedAnalgesicsAnti-Inflammatory Agents, Non-SteroidalAspirinDipyroneElective Surgical ProceduresFemaleHospitalizationHumansMaleMiddle AgedPlatelet AggregationPlatelet Aggregation InhibitorsPostoperative PeriodAnalgesicsAnti-Inflammatory Agents, Non-SteroidalArachidonic AcidAspirinDipyronePlatelet Aggregation InhibitorsAspirinDipyroneDrug interactionsMetamizolePlatelet aggregationSurgery

Identifiers

PMID30778625
OpenAlexW2916836853

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.