Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2019
A Case for Promoting Movement Medicine: Preventing Disability in the LIFE Randomized Controlled Trial.
Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01072500 (The LIFE Study - Lifestyle Interventions and Independence for Elders), which is not on this map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The LIFE Study - Lifestyle Interventions and Independence for Elders
Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Examining the Influence of Promoting Physical Activity Bouts on Adolescent Movement Dispersion: Secondary Analysis of a Randomized Control Trial.Journal for specialists in pediatric nursing : JSPN · 2026Trial
- Intervening on exercise and daylong movement for weight loss maintenance in older adults: A randomized, clinical trial.Obesity (Silver Spring, Md.) · 2022Trial
- Automated Muscle Measurement on Chest CT Predicts All-Cause Mortality in Older Adults From the National Lung Screening Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- The Tribulations of Trials: Lessons Learnt Recruiting 777 Older Adults Into REtirement in ACTion (REACT), a Trial of a Community, Group-Based Active Aging Intervention Targeting Mobility Disability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- Relationships Between Profiles of Physical Activity and Major Mobility Disability in the LIFE Study.Journal of the American Geriatrics Society · 2020Trial
- Validation of Pure and Total Movement Dispersion Variables as Measures of the Distribution of Daily Activity Using Accelerometers: A Secondary Analysis of a Prospective Cohort.Journal of public health (Berlin, Germany) · 2026Article
- Social Determinants of Health in Physiatry: Challenges and Opportunities for Clinical Decision Making and Improving Treatment Precision.Frontiers in public health · 2021Review
- Calorie Restriction and Aging in Humans.Annual review of nutrition · 2020Article
- Impact and Lessons From the Lifestyle Interventions and Independence for Elders (LIFE) Clinical Trials of Physical Activity to Prevent Mobility Disability.Journal of the American Geriatrics Society · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundThe movement profile of older adults with compromised function is unknown, as is the relationship between these profiles and the development of major mobility disability (MMD)-a critical clinical outcome. We first describe the dimensions of movement in older adults with compromised function and then examine whether these dimensions predict the onset of MMD.
methodsOlder adults at risk for MMD (N = 1,022, mean age = 78.7 years) were randomized to receive a structured physical activity intervention or health education control. We assessed MMD in 6-month intervals (average follow-up of 2.2 years until incident MMD), with activity assessed at baseline, 6-, 12- and 24-month follow-up via accelerometry.
resultsA principal components analysis of 11 accelerometer-derived metrics yielded three components representing lifestyle movement (LM), extended bouts of moderate-to-vigorous physical activity (MVPA), and stationary body posture. LM accounted for the greatest proportion of variance in movement (53%). Within health education, both baseline LM (HR = 0.74; 95% CI 0.62 to 0.88) and moderate-to-vigorous physical activity (HR = 0.69; 95% CI 0.54 to 0.87) were associated with MMD, whereas only LM was associated with MMD within physical activity (HR = 0.74; 95% CI 0.61 to 0.89). There were similar nonlinear relationships present for LM in both physical activity and health education (p < .04), whereby risk for MMD was lower among individuals with higher levels of LM.
conclusionsBoth LM and moderate-to-vigorous physical activity should be central in treatment regimens for older adults at risk for MMD.
trial registrationclinicaltrials.gov Identifier NCT01072500.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.