Evidence map›Paper›PMID 30778481›Full record

ArticleOrganic & biomolecular chemistry2019

Glycoconjugate synthesis using chemoselective ligation.

Shuihong Cheng, Paeton L Wantuch, Megan E Kizer, Dustin R Middleton, Ruitong Wang, Mikaela DiBello, Mingli Li, Xing Wang, Xuebing Li, Vasanthi Ramachandiran and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 18 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 5 countries.

Shuihong ChengCAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Chaoyang, China.
Paeton L Wantuch
Megan E Kizer
Dustin R Middleton
Ruitong Wang
Mikaela DiBello
Mingli Li
Xing Wang
Xuebing Li
Vasanthi Ramachandiran
Fikri Y Avci
Fuming Zhang
Xing Zhang
Robert J Linhardt
Rensselaer Polytechnic Institute · USChinese Academy of Sciences · CNUniversity of Georgia · USEmory University · US

Funding

Molecular Mechanisms for Carbohydrate Presentation to CD4+ T cells by MHCII PathwayR01AI123383 · NIAID · UNIVERSITY OF GEORGIA · PI Fikri Y Avci · 2016 to 2026
$4.2M
Endothelial glycocalyx reconstitution during sepsisR01HL125371 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LINHARDT, ROBERT J, SCHMIDT, ERIC PETER · 2014 to 2018
$3.4M
The role ofglycosaminoglycan N-sulfation in glomerular biology/pathobiologyR01DK111958 · NIDDK · LOUISIANA STATE UNIV HSC SHREVEPORT · PI MCCARTHY, KEVIN JOHN · 2017 to 2021
$2.6M
Heparan sulfate in neurophysiology and neurological disordersR01NS088496 · NINDS · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI YAMAGUCHI, YU · 2015 to 2018
$1.7M
Glycoscience Training ProgramT32GM107004 · NIGMS · UNIVERSITY OF GEORGIA · PI AMSTER, I JONATHAN, HALTIWANGER, ROBERT S. · 2014 to 2021
$1.3M
NHLBI NIH HHS R01 HL125371NIAID NIH HHS R01 AI123383NIDDK NIH HHS R01 DK111958NIGMS NIH HHS T32 GM107004NINDS NIH HHS R01 NS088496
6 · The paper itself

Abstract

Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates.

Indexed as

AdipatesAmino Acid SequenceChemistry Techniques, SyntheticGlycoconjugatesGlycopeptidesModels, MolecularMolecular ConformationSubstrate SpecificityAdipatesadipic acidGlycoconjugatesGlycopeptides

Identifiers

PMID30778481
PMCPMC6431789
OpenAlexW2914411430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.