ArticleFrontiers in chemistry2019
Peptide Functionalization of Gold Nanoparticles for the Detection of Carcinoembryonic Antigen in Blood Plasma via SPR-Based Biosensor.
Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- An effect of silver arsenic sulfide and gallium sulfide dielectric materials in SPR refractive sensor: a numerical study.Scientific reports · 2026Article
- QuPepFold: A python package for hybrid quantum-classical protein folding simulations with CVaR-optimized VQE.PloS one · 2026Article
- Plasmonic Film with Diluted Nanostructures for Light Energy Harvesting and Sensing.ACS applied optical materials · 2025Article
- Recent advances in surface plasmon resonance for the detection of ovarian cancer biomarkers: a thorough review.Mikrochimica acta · 2024Review
- Gold-binding peptide as a selective layer for electrochemical detection of SARS-CoV-2 antibodies.Talanta · 2023Article
- A Multiple-Array SPRi Biosensor as a Tool for Detection of Gynecological-Oncological Diseases.Biosensors · 2023Article
- Two Biosensors for the Determination of Interleukin-6 in Blood Plasma by Array SPRi.Biosensors · 2022Article
- Surface Plasmon Resonance Immunosensor with Antibody-Functionalized Magnetoplasmonic Nanoparticles for Ultrasensitive Quantification of the CD5 Biomarker.ACS applied materials & interfaces · 2022Article
- Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review.Sensors (Basel, Switzerland) · 2022Review
- Hairpin oligosensor using SiQDs: Förster resonance energy transfer study and application for miRNA-21 detection.Analytical and bioanalytical chemistry · 2022Article
- Article
- A Fabry-Pérot cavity coupled surface plasmon photodiode for electrical biomolecular sensing.Nature communications · 2021Article
- Review
- Recent advances in functionalization of plasmonic nanostructures for optical sensing.Mikrochimica acta · 2021Review
- Low-Fouling Substrates for Plasmonic Sensing of Circulating Biomarkers in Biological Fluids.Biosensors · 2020Review
- Noble Metal-Assisted Surface Plasmon Resonance Immunosensors.Sensors (Basel, Switzerland) · 2020Review
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4 authors.
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Abstract
Nanoparticles functionalized with specific biological recognition molecules play a major role for sensor response enhancement in surface plasmon resonance (SPR) based biosensors. The functionalization procedure of such nanoparticles is crucial, since it influences their interactions with the environment and determines their applicability to biomolecular detection in complex matrices. In this work we show how the ζ-potential (Zpot) of bio-functionalized gold spherical NPs (Bio-NPs) is related to the SPR sensor response enhancement of an immune-sandwich-assay for the detection of the carcinoembryonic antigen (CEA), a cancer marker for colorectal carcinomas. In particular, we prepare bio-functional nanoparticles by varying the amount of peptide (either streptavidin or antibody against CEA) bound on their surface. Specific and non-specific sensor responses, reproducibility, and colloidal stability of those bio-functional nanoparticles are measured via SPR and compared to ζ-potential values. Those parameters are first measured in buffer solution, then measured again when the surface of the biosensor is exposed to blood plasma, and finally when the nanoparticles are immersed in blood plasma and flowed overnight on the biosensor. We found that ζ-potential values can guide the design of bio-functional NPs with improved binding efficiency and reduced non-specific sensor response, suitable reproducibility and colloidal stability, even in complex matrixes like blood plasma.
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