Evidence map›Paper›PMID 30778372›Full record

ArticleFrontiers in genetics2018

Characterization of DNA Methylation Associated Gene Regulatory Networks During Stomach Cancer Progression.

Jun Wu, Yunzhao Gu, Yawen Xiao, Chao Xia, Hua Li, Yani Kang, Jielin Sun, Zhifeng Shao, Zongli Lin, Xiaodong Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jun WuSchool of Life Sciences, East China Normal University, Shanghai, China.
Yunzhao GuBio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yawen XiaoDepartment of Automation, Shanghai Jiao Tong University, Shanghai, China.
Chao XiaBio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Hua LiBio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yani KangBio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Jielin SunShanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
Zhifeng ShaoBio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Zongli LinCharles L. Brown Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, VA, United States.
Xiaodong ZhaoShanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
Shanghai Jiao Tong University · CNEast China Normal University · CNUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA methylation plays a critical role in tumorigenesis through regulating oncogene activation and tumor suppressor gene silencing. Although extensively analyzed, the implication of DNA methylation in gene regulatory network is less characterized. To address this issue, in this study we performed an integrative analysis on the alteration of DNA methylation patterns and the dynamics of gene regulatory network topology across distinct stages of stomach cancer. We found the global DNA methylation patterns in different stages are generally conserved, whereas some significantly differentially methylated genes were exclusively observed in the early stage of stomach cancer. Integrative analysis of DNA methylation and network topology alteration yielded several genes which have been reported to be involved in the progression of stomach cancer, such as

Indexed as

DNA methylationgene regulation networkstomach cancersystem leveltumor stages

Identifiers

PMID30778372
PMCPMC6369581
OpenAlexW2911604705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.