Evidence map›Paper›PMID 30778350›Full record

ArticleFrontiers in immunology2019

Protective Effects of Aryl Hydrocarbon Receptor Signaling in Celiac Disease Mucosa and in Poly I:C-Induced Small Intestinal Atrophy Mouse Model.

Vincenzo Dinallo, Irene Marafini, Davide Di Fusco, Antonio Di Grazia, Federica Laudisi, Rami Dwairi, Omero A Paoluzi, Giovanni Monteleone, Ivan Monteleone

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 23 citations in OpenAlex.

  1. Novel probiotic preparation withMicrobiology spectrum · 2024
    Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Aryl Hydrocarbon Receptor Signalling in the Control of Gut Inflammation.International journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. AHR in the intestinal microenvironment: safeguarding barrier function.Nature reviews. Gastroenterology & hepatology · 2021
    Review
  16. Article
  17. Review
  18. To Be or Not to Be a Pathogen:Frontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Vincenzo DinalloDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Irene MarafiniDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Davide Di FuscoDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Antonio Di GraziaDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Federica LaudisiDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Rami DwairiDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Omero A PaoluziDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Giovanni MonteleoneDepartment of Systems Medicine, Gastroenterology, University of Tor Vergata, Rome, Italy.
Ivan MonteleoneDepartment of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy.
University of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aryl hydrocarbon receptor (AhR), a transcription factor activated by a large number of natural and synthetic agents, modulates the activity of immune cells in the gut and represents an important link between the environment and immune-mediated pathologies. In this study, we investigated the role of AhR in celiac disease (CD), a gluten-driven enteropathy. AhR expression was evaluated in intestinal biopsies taken from patients with CD and controls by real-time polymerase chain reaction (PCR), immunohistochemistry and flow cytometry. AhR was also analyzed in

Indexed as

AdultAnimalsAtrophyBasic Helix-Loop-Helix ProteinsBiopsyCarbazolesCeliac DiseaseDiet, Gluten-FreeDisease Models, AnimalFemaleGene Knockout TechniquesGliadinHumansInterferon-gammaIntestinal MucosaIntestine, Small6-formylindolo(3,2-b)carbazoleAHR protein, humanBasic Helix-Loop-Helix ProteinsCarbazolesGliadinIFNG protein, humanInterferon-gammaPoly I-CProtective AgentsReceptors, Aryl HydrocarbonTNF protein, humanTumor Necrosis Factor-alphaaryl hydrocarbon receptor (AhR)celiac diseaseIFN-gammainflammationintestinal atrophy

Identifiers

PMID30778350
PMCPMC6369162
OpenAlexW2911859020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.