ArticleFrontiers in physiology2019
Polyscore of Non-invasive Cardiac Risk Factors.
Article in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 14 citations in OpenAlex.
- The 'Advancing Cardiovascular Risk Identification with Structured Clinical Documentation and Biosignal Derived Phenotypes Synthesis' project: conceptual design, project planning, and first implementation experiences.European heart journal. Digital health · 2025Article
- Expiration-Triggered Sinus Arrhythmia Predicts Mortality Risk in the General Elderly Population.Journal of cardiovascular development and disease · 2025Article
- Respiratory rate and its associations with disease and lifestyle factors in the general population - results from the KORA-FF4 study.PloS one · 2025Article
- Risk assessment of post-myocardial infarction patients with preserved ejection fraction using 45-min short resting Holter electrocardiographic recordings.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023Article
- Phenotyping autonomic neuropathy using principal component analysis.Autonomic neuroscience : basic & clinical · 2023Article
- Interpreting resting heart rate variability in complex populations: the role of autonomic reflexes and comorbidities.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- The Polyscore of autonomic parameters predicts mortality and identifies low-risk individuals among diabetic survivors of acute myocardial infarction.Scientific reports · 2022Article
- Contributions of the heart rate turbulence method to risk stratification in patients after myocardial infarction: a review.American journal of cardiovascular disease · 2022Review
- Polyscore of autonomic parameters for risk stratification of the elderly general population: the Polyscore study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- Reconstruction of the respiratory signal through ECG and wrist accelerometer data.Scientific reports · 2020Article
- Sex and race differences in J-Tend, J-Tpeak, and Tpeak-Tend intervals.Scientific reports · 2019Article
- Heart rate variability categories of fluctuation amplitude and complexity: diagnostic markers of fetal development and its disturbances.Physiological measurement · 2019Article
- CrossTalk proposal: Heart rate variability is a valid measure of cardiac autonomic responsiveness.The Journal of physiology · 2019Article
- Heart rate turbulence assessed through ergometry after myocardial infarction: a feasibility study.Sao Paulo medical journal = Revista paulista de medicinaArticle
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Non-invasive risk stratification of cardiac patients has been the subject of numerous studies. Most of these investigations either researched unique risk predictors or compared the predictive power of different predictors. Fewer studies suggested a combination of a small number of non-invasive indices to increase the accuracy of high-risk group selection. To advance non-invasive risk assessment of cardiac patients, we propose a combination score (termed the Polyscore) of seven different cardiac risk stratifiers that predominantly quantify autonomic cardiovascular control and regulation, namely the slope of heart rate turbulence, deceleration capacity of heart rate, non-invasively assessed baroreflex sensitivity, resting respiration frequency, expiration triggered sinus arrhythmia, post-ectopic potentiation of systolic blood pressure, and frequency of supraventricular and ventricular ectopic beats. These risk stratification tests have previously been researched and their dichotomies defining abnormal results have been derived from previous reports. The Polyscore combination was defined as the number of positive tests among these seven risk predictors, giving a numerical scale which ranges from 0 (all tests normal) to 7 (all tests abnormal). The Polyscore was tested in a population of 941 contemporarily treated survivors of acute myocardial infarction (median age 61 years, 182 females) of whom 72 (7.65%) died during a 5-year follow-up. In these patients, all the risk predictors combined in the Polyscore were assessed during in-hospital 30-min simultaneous non-invasive recordings of high-frequency orthogonal electrocardiogram, continuous blood pressure and respiration. Compared to Polyscore 0 stratum, the hazard ratios of mortality during follow-up increased almost exponentially in strata 1 through 7 (vs. stratus 0, the hazard ratios were 1.37, 1.96, 7.03, 15.0, 35.7, 48.2, and 114, in strata 1 to 7, respectively;
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