ArticleNature immunology2019
The transcription factor c-Myb regulates CD8
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Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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125citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
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Who cites it
125 citing papers in PubMed, 177 citations in OpenAlex.
- Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores.The Journal of allergy and clinical immunology · 2026Article
- CCR5+ CD8+ T Cells Are Associated with Poor Response to PD-1 Blockade Therapy.International journal of molecular sciences · 2026Article
- KLF4 overexpression in CAR T cells enhances antitumor potency by preventing exhaustion.Journal for immunotherapy of cancer · 2026Article
- Overcoming T cell tolerance to tumor self-antigens through catch-bond engineering.Science (New York, N.Y.) · 2026Article
- Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy.Nature immunology · 2026Article
- BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells.Nature immunology · 2026Article
- Regulators of CD8Nature reviews. Immunology · 2026Review
- Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity.Cell host & microbe · 2026Article
- Single-Cell Clonal Lineage Tracing Identifies the Transcriptional Program Controlling the Cell-Fate Decisions by Neoantigen-Specific CD8+ T Cells.Cancer immunology research · 2026Article
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Memory-like CD8Frontiers in immunology · 2026Article
- Stem-like T cells in cancer immunotherapy: biology, regulation and therapeutic targeting.Frontiers in immunology · 2026Review
- Stem-like CD4 T cells in tumors: an emerging framework for antitumor immunity.Frontiers in immunology · 2026Review
- Thy1 retroviral reporters: a versatile platform for congenic background-independent adoptive transfer and CD8Frontiers in immunology · 2026Article
- Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence.BMC biology · 2025Article
- Brain and Immune System Part II-An Integrative View upon Spatial Orientation, Learning, and Memory Function.International journal of molecular sciences · 2025Review
- Uncovering the individual immunotherapeutic roles of PTPN1 and PTPN2 in T cells during dual inhibition.iScience · 2025Article
- SATB1 is a key regulator of quiescence in stem-like CD8Nature immunology · 2025Article
- Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy.Cellular & molecular immunology · 2025Review
- BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells.The Journal of experimental medicine · 2025Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
21 authors at 5 institutions in 2 countries.
Sanjivan GautamExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Jessica FioravantiExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6263-4306
Wei ZhuDepartment of Bioinformatics, Inova Translational Medicine Institute, Fairfax, VA, USA.
John B Le GallExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Philip BrohawnMedImmune, Gaithersburg, MD, USA.
Neal E LaceyExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3633-5924
Jinhui HuExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
James D HockerExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Nga Voong HawkExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Veena KapoorExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
William G TelfordExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Devikala GurusamySurgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Zhiya YuSurgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Avinash BhandoolaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Hai-Hui XueDepartment of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0002-9163-7669
Rahul RoychoudhuriLaboratory of Lymphocyte Signaling and Development, Babraham Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-5392-1853
Brandon W HiggsMedImmune, Gaithersburg, MD, USA.ORCID http://orcid.org/0000-0002-2951-0245
Nicholas P RestifoSurgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Timothy P BenderDepartment of Microbiology, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-9216-1212
Yun JiExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6340-7009
Luca GattinoniExperimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. gattinol@mail.nih.gov.ORCID http://orcid.org/0000-0003-2239-3282
National Cancer Institute · USBabraham Institute · GBCarter Center · USInova Fairfax Hospital · USUniversity of Iowa · US
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0MT cell Development and RegenerationZIABC011633 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BHANDOOLA, AVINASH · 2015 to 2025
$20.5MProgramming T Cell Fates for Therapeutic UseZIABC011480 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GATTINONI, LUCA · 2013 to 2019
$7.4MCONDITIONAL MUTAGENESIS TO STUDY C MYB FUNCTIONR01CA085842 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI BENDER, TIMOTHY P. · 2001 to 2011
$3.2Mc-Myb controls survival, proliferation and differentiation during B-lymphopoiesisR01GM100776 · NIGMS · UNIVERSITY OF VIRGINIA · PI BENDER, TIMOTHY P. · 2011 to 2014
$1.1MBiotechnology and Biological Sciences Research Council BB/N007794/1Biotechnology and Biological Sciences Research Council BBS/E/B/000C0407Biotechnology and Biological Sciences Research Council BBS/E/B/000C0409Cancer Research UK 22597Intramural NIH HHS ZIA BC011480Medical Research Council MC_UP_1502/3Medical Research Council MR/S024468/1NCI NIH HHS R01 CA085842NIGMS NIH HHS R01 GM100776Wellcome Trust
Abstract
Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem cells in the CD8
Indexed as
AnimalsCD8-Positive T-LymphocytesCell DifferentiationCell Line, TumorHEK293 CellsHumansImmunologic MemoryLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMice, Inbred C57BLMice, KnockoutMice, TransgenicNeoplasms, ExperimentalProto-Oncogene Proteins c-mybStem CellsT Cell Transcription Factor 1Proto-Oncogene Proteins c-mybT Cell Transcription Factor 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.