ArticleNature immunology2019
Quantifying in situ adaptive immune cell cognate interactions in humans.
Article in Nature immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Characterization of tumor microenvironment and cell interaction patterns in testicular and diffuse large B-cell lymphomas.Haematologica · 2025Article
- AI-based hardware and software tools in microscopy to boost research in immunology and virology.Frontiers in immunology · 2025Review
- Pseudo-spectral angle mapping for pixel and cell classification in highly multiplexed immunofluorescence images.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Machine learning predictions of T cell antigen specificity from intracellular calcium dynamics.Science advances · 2024Article
- Pseudo-spectral angle mapping for automated pixel-level analysis of highly multiplexed tissue image data.bioRxiv : the preprint server for biology · 2024Article
- In vivo imaging of inflammatory response in cancer research.Inflammation and regeneration · 2023Review
- Specific in situ inflammatory states associate with progression to renal failure in lupus nephritis.The Journal of clinical investigation · 2022Article
- Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging.Immunological reviews · 2022Review
- Clinical Impact of Immune Cells and Their Spatial Interactions in Diffuse Large B-Cell Lymphoma Microenvironment.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022Article
- Rapid video-based deep learning of cognate versus non-cognate T cell-dendritic cell interactions.Scientific reports · 2022Article
- Spatial immunoprofiling of the intratumoral and peritumoral tissue of renal cell carcinoma patients.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Article
- Cellular aspects of the pathogenesis of lupus nephritis.Current opinion in rheumatology · 2021Review
- Quantifying the effects of biopsy fixation and staining panel design on automatic instance segmentation of immune cells in human lupus nephritis.Journal of biomedical optics · 2021Article
- Artificial intelligence and the hunt for immunological disorders.Current opinion in allergy and clinical immunology · 2020Review
- Tumor Targeting by αACS nano · 2020Article
- Cancer systems immunology.eLife · 2020Review
- Autoimmunity and organ damage in systemic lupus erythematosus.Nature immunology · 2020Review
- Anti-vimentin antibodies: a unique antibody class associated with therapy-resistant lupus nephritis.Lupus · 2020Article
- Protecting the kidney in systemic lupus erythematosus: from diagnosis to therapy.Nature reviews. Rheumatology · 2020Review
- Multilabel segmentation of cancer cell culture on vascular structures with deep neural networks.Journal of medical imaging (Bellingham, Wash.) · 2020Article
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10 authors.
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Abstract
Two-photon excitation microscopy (TPEM) has revolutionized the understanding of adaptive immunity. However, TPEM usually requires animal models and is not amenable to the study of human disease. The recognition of antigen by T cells requires cell contact and is associated with changes in T cell shape. We postulated that by capturing these features in fixed tissue samples, we could quantify in situ adaptive immunity. Therefore, we used a deep convolutional neural network to identify fundamental distance and cell-shape features associated with cognate help (cell-distance mapping (CDM)). In mice, CDM was comparable to TPEM in discriminating cognate T cell-dendritic cell (DC) interactions from non-cognate T cell-DC interactions. In human lupus nephritis, CDM confirmed that myeloid DCs present antigen to CD4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.