ArticleNature cell biology2019
NAD
Abstract read
In one paragraph
Article in Nature cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 2 pooled it
22.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
249 citing papers in PubMed, 2 syntheses or guidelines pooled it, 380 citations in OpenAlex.
- Rejuvenation of Bone Marrow Mesenchymal Stem Cells: Mechanisms and Their Application in Senile Osteoporosis Treatment.Biomolecules · 2025Pooled it
- Importance of circulating adipocytokines in multiple myeloma: a systematic review and meta-analysis based on case-control studies.BMC endocrine disorders · 2022Pooled it
- Hepatocyte senescence in metabolic dysfunction-associated steatotic liver disease (MASLD).Hepatology communications · 2026Review
- Ubiquitination-mediated degradation of NLRX1 drives metabolic vulnerability and accelerates intervertebral disc degeneration.Cell death and differentiation · 2026Article
- Endothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.Science advances · 2026Article
- NAMPT activation uncovers a senescence-specific vulnerability and promotes healthy aging in combination with NAM.bioRxiv : the preprint server for biology · 2026Article
- Simulated Microgravity Induced Mesenchymal Stem Cell Senescence via the Activation of Cytosolic mtDNA-cGAS-STING Axis.Journal of cellular physiology · 2026Article
- The mitochondrial unfolded protein response in human microglia disrupts neuronal-glial communication and promotes senescence.Nature neuroscience · 2026Article
- The chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.Nature aging · 2026Article
- Cellular senescence: the "hidden driver" in chronic inflammatory skin disorders.Immunity & ageing : I & A · 2026Review
- MAP2K6 reprograms NADCell death & disease · 2026Article
- Skin aging: mechanisms, evaluation, and rejuvenation.The EMBO journal · 2026Review
- Hierarchical endpoints and win statistics for geromedicine trials.Nature aging · 2026Review
- Exogenous Nucleotides as Functional Food Supplements: A Bibliometric Analysis of Global Research Trends (2000-2025).Foods (Basel, Switzerland) · 2026Review
- Inflammaging Beyond Biomarkers: Molecular Mechanisms and Therapeutic Opportunities.Current issues in molecular biology · 2026Review
- Molecular mechanisms and recent advances in cellular senescence.Cell & bioscience · 2026Review
- Nuclear export of R-loop by the DDX1 and XPO1 complex promotes senescence-associated secretory phenotype and inflammaging.Nature aging · 2026Article
- Nutrition Information Briefs - Niacin.Advances in nutrition (Bethesda, Md.) · 2026Article
- Exposure to high doses of tyre antioxidant 6PPD causes senescence to induce unexplained miscarriage by suppressing BAZ1B-mediated ubiquitination degradation of P21.EBioMedicine · 2026Article
- Chronic Kidney Disease and Cellular Senescence.International journal of molecular sciences · 2026Review
189 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 4 institutions in 1 country.
Timothy NacarelliGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Lena LauDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
Takeshi FukumotoGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Joseph ZundellGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Nail FatkhutdinovGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Shuai WuGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Katherine M AirdGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Osamu IwasakiGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Andrew V KossenkovCenter for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA, USA.
David SchultzHigh-throughput Screening Core, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ken-Ichi NomaGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-5187-6788
Joseph A BaurDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Zachary SchugMolecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4197-8227
Hsin-Yao TangProteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, USA.
David W SpeicherCenter for Systems and Computational Biology, The Wistar Institute, Philadelphia, PA, USA.
Gregory DavidDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-1849-3232
Rugang ZhangGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA. rzhang@wistar.org.ORCID http://orcid.org/0000-0002-7255-2360
The Wistar Institute · USNew York University · USHigh Throughput Biology (United States) · USUniversity of Pennsylvania · US
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MSTRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI BERGER, SHELLEY L · 2008 to 2022
$28.3MSPORE in Ovarian CancerP50CA228991 · NCI · JOHNS HOPKINS UNIVERSITY · PI Tian-Li Wang · 2018 to 2026
$20.5MTRAINING PROGRAM IN BASIC CANCER RESEARCHT32CA009171 · NCI · WISTAR INSTITUTE · PI Alessandro Gardini · 1985 to 2026
$15.3MTargeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1MMechanistic basis and therapeutic strategies for ARID1A mutation in ovarian cancerR01CA202919 · NCI · WISTAR INSTITUTE · PI Xi Chen, Rugang Zhang · 2016 to 2026
$4.1MIdentification of Ovarian Cancer Plasma BiomarkersR01CA131582 · NCI · WISTAR INSTITUTE · PI SPEICHER, DAVID W. · 2009 to 2018
$4.1MRole of BRCA1 Pathway in Regulating Oncogene-Induced SenescenceR01CA160331 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$4.0MTargeting EZH2 in CARM1-expressing epithelial ovarian cancerR01CA163377 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$3.7MAdvancing Cancer Research through Comprehensive Proteomics and Metabolomics AnalysesR50CA221838 · NCI · WISTAR INSTITUTE · PI Hsin-Yao Tang · 2017 to 2026
$2.1MRegulation of Cellular Senescence and Oncogenic Transformation by Sin3B.R01CA148639 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DAVID, GREGORY · 2011 to 2015
$2.0MIntegrative Approach to Comprehensive Analysis of High Throughput Data on a Cancer Center LevelR50CA211199 · NCI · WISTAR INSTITUTE · PI Andrew V Kossenkov · 2016 to 2026
$1.6MNCI NIH HHS F31 CA206387NCI NIH HHS P30 CA010815NCI NIH HHS P50 CA228991NCI NIH HHS R00 CA194309NCI NIH HHS R01 CA131582NCI NIH HHS R01 CA148639NCI NIH HHS R01 CA160331NCI NIH HHS R01 CA163377NCI NIH HHS R01 CA202919NCI NIH HHS R21 CA155736NCI NIH HHS R50 CA211199NCI NIH HHS R50 CA221838NCI NIH HHS T32 CA009171NIA NIH HHS P01 AG031862NIDDK NIH HHS R01 DK098656NIH HHS S10 OD023586NIH HHS S10 OD023658
Abstract
Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). NAD
Indexed as
Cellular SenescenceAnimalsCell LineCytokinesFibroblastsGene Expression RegulationHumansInflammation MediatorsMice, Inbred NODMice, KnockoutMice, SCIDNADNicotinamide Phosphoribosyltransferasep38 Mitogen-Activated Protein KinasesPhenotypeSignal TransductionCytokinesInflammation MediatorsNADNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, humanp38 Mitogen-Activated Protein Kinases
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.