ArticleNature chemistry2019
Liquid-liquid phase separation during amphiphilic self-assembly.
Article in Nature chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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Who cites it
63 citing papers in PubMed.
- Multilayer mesoporous vesosomes of block copolymer.Nature communications · 2026Article
- Preparation of polycaprolactone-based 2D platelets via living crystallization-driven self-assembly.Nature protocols · 2026Review
- α-Synuclein Forms Distinct Micelle-Like Assemblies at Low Ionic Strengths.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Programmable Multiphasic Condensates Formed via Evaporation-Induced Phase Separation of Minimal Peptide Model.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Characterization of dynamics of encapsulated small molecule Nile red in biodegradable polymer using 2D IR methods.The Journal of chemical physics · 2026Article
- Liquid Phase TEM of Diffusing Emulsion Droplets.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Graphene-Based Liquid Cell Designs for In Situ Liquid-Phase Transmission Electron Microscopy: Recent Developments and Perspectives.Small science · 2025Review
- Differential conformational expansion of NUP98-HOXA9 oncoprotein from nanosized assemblies to macrophases.Nature communications · 2025Article
- Residue-Resolved Liquid-State Hyperpolarized NMR of Peptide Condensate Surfaces.Journal of the American Chemical Society · 2025Article
- Coacervate Vesicles as Adaptive Platforms for Synthetic Biology and Smart Materials.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Emergence of conformational diversity and complexity of supramolecular structure by the interaction of a simple molecule with a uniform surface.Communications chemistry · 2025Article
- Pushing the Frontiers: Artificial Intelligence (AI)-Guided Programmable Concepts in Binary Self-Assembly of Colloidal Nanoparticles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Aqueous Self-Assembly of Cylindrical and Tapered Bottlebrush Block Copolymers.Angewandte Chemie (International ed. in English) · 2025Article
- R5 Peptides Constitute Condensed Phases with Liquid-Like Properties in Biomimetic Silica Capsules.The journal of physical chemistry letters · 2025Article
- In Situ Polymerization of Long Alkyl Chain Functional Groups Enhances the Oil-Water Separation Performance of Porous Organic Polymers.Molecules (Basel, Switzerland) · 2025Article
- The Influence of Ionizing Radiation on Quantification for In Situ and Operando Liquid-Phase Electron Microscopy.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Designing polymersomes with surface-integrated nanoparticles through hierarchical phase separation.Nature communications · 2025Article
- Real-time visualisation of fast nanoscale processes during liquid reagent mixing by liquid cell transmission electron microscopy.Communications chemistry · 2025Article
- 3D Nanofabrication via Directed Material Assembly: Mechanism, Method, and Future.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Ruthenium(II) Lipid-Mimics Drive Lipid Phase Separation to Arouse Autophagy-Ferroptosis Cascade for Photoimmunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The self-assembly of amphiphilic molecules in solution is a ubiquitous process in both natural and synthetic systems. The ability to effectively control the structure and properties of these systems is essential for tuning the quality of their functionality, yet the underlying mechanisms governing the transition from molecules to assemblies have not been fully resolved. Here we describe how amphiphilic self-assembly can be preceded by liquid-liquid phase separation. The assembly of a model block co-polymer system into vesicular structures was probed through a combination of liquid-phase electron microscopy, self-consistent field computations and Gibbs free energy calculations. This analysis shows the formation of polymer-rich liquid droplets that act as a precursor in the bottom-up formation of spherical micelles, which then evolve into vesicles. The liquid-liquid phase separation plays a role in determining the resulting vesicles' structural properties, such as their size and membrane thickness, and the onset of kinetic traps during self-assembly.
Identifiers
30778139What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.