Evidence map›Paper›PMID 30778137›Full record

ArticleScientific reports2019

CT Enhancement and 3D Texture Analysis of Pancreatic Neuroendocrine Neoplasms.

Mirko D'Onofrio, Valentina Ciaravino, Nicolò Cardobi, Riccardo De Robertis, Sara Cingarlini, Luca Landoni, Paola Capelli, Claudio Bassi, Aldo Scarpa

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Radiomics in differential diagnosis of pancreatic tumors.European journal of radiology open · 2025
    Article
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  14. A Machine Learning Approach Using [Molecular imaging and biology · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Update on quantitative radiomics of pancreatic tumors.Abdominal radiology (New York) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Mirko D'OnofrioDepartment of Radiology, G.B. Rossi Hospital - University of Verona, Verona, Italy. mirko.donofrio@univr.it.
Valentina CiaravinoDepartment of Radiology, G.B. Rossi Hospital - University of Verona, Verona, Italy.
Nicolò CardobiDepartment of Radiology, Ospedale Civile Maggiore, Verona, Italy.
Riccardo De RobertisDepartment of Radiology, Ospedale Civile Maggiore, Verona, Italy.
Sara CingarliniDepartment of Oncology, G.B. Rossi Hospital - University of Verona, Verona, Italy.
Luca LandoniDepartment of General and Pancreatic Surgery, Pancreas Institute, G.B. Rossi Hospital - University of Verona, Verona, Italy.
Paola CapelliDepartment of Pathology, Pancreas Institute, G.B. Rossi Hospital - University of Verona, Verona, Italy.
Claudio BassiDepartment of General and Pancreatic Surgery, Pancreas Institute, G.B. Rossi Hospital - University of Verona, Verona, Italy.
Aldo ScarpaDepartment of Pathology, Pancreas Institute, G.B. Rossi Hospital - University of Verona, Verona, Italy.ORCID 0000-0003-1678-739X
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To evaluate pancreatic neuroendocrine neoplasms (panNENs) grade prediction by means of qualitative and quantitative CT evaluation, and 3D CT-texture analysis. Patients with histopathologically-proven panNEN, availability of Ki67% values and pre-treatment CT were included. CT images were retrospectively reviewed, and qualitative and quantitative images analysis were done; for quantitative analysis four enhancement-ratios and three permeability-ratios were created. 3D CT-texture imaging analysis was done (Mean Value; Variance; Skewness; Kurtosis; Entropy). Subsequently, these features were compared among the three grading (G) groups. 304 patients affected by panNENs were considered, and 100 patients were included. At qualitative evaluation, frequency of irregular margins was significantly different between tumor G groups. At quantitative evaluation, for all ratios, comparisons resulted statistical significant different between G1 and G3 groups and between G2 and G3 groups. At 3D CT-texture analysis, Kurtosis resulted statistical significant different among three G groups and Entropy resulted statistical significant different between G1 and G3 and between G2 and G3 groups. Quantitative CT evaluation of panNENs can predict tumor grade, discerning G1 from G3 and G2 from G3 tumors. CT-texture analysis can predict panNENs tumor grade, distinguishing G1 from G3 and G2 from G3, and G1 from G2 tumors.

Indexed as

AdolescentAdultAgedAged, 80 and overFemaleHumansImaging, Three-DimensionalMaleMiddle AgedNeoplasm GradingNeuroendocrine TumorsPancreatic NeoplasmsRadiographic Image EnhancementRetrospective StudiesTomography, X-Ray ComputedYoung Adult

Identifiers

PMID30778137
PMCPMC6379382
OpenAlexW2914460729

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.