ArticleScientific reports2019
Persistent autonomic dysfunction and bladder sensitivity in primary dysmenorrhea.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- What is known about adolescent dysmenorrhoea in (and for) community health settings?Frontiers in reproductive health · 2024Pooled it
- The value of a non-invasive bladder sensitivity paradigm in chronic pelvic pain.Reproduction & fertility · 2026Article
- Integrating Superior Hypogastric Plexus Block with Conventional Therapies: Advancements in Chronic Pelvic Pain Management.Journal of pharmacy & bioallied sciences · 2025Review
- Impaired gastric and urinary but preserved cardiac interoception in women with endometriosis.PloS one · 2025Article
- How our hearts beat together: a study on physiological synchronization based on a self-paced joint motor task.Scientific reports · 2023Article
- Scientific Knowledge Graph of Dysmenorrhea: A Bibliometric Analysis from 2001 to 2021.Journal of pain research · 2023Article
- Myofascial Pain Syndrome in Women with Primary Dysmenorrhea: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2022Article
- Prevalence of chronic pelvic pain and primary dysmenorrhea in women of reproductive age in Ecuador.BMC women's health · 2022Article
- Effects of Stimulus Frequency, Intensity, and Sex on the Autonomic Response to Transcutaneous Vagus Nerve Stimulation.Brain sciences · 2022Article
- Impact of Endometriosis on Life-Course Potential: A Narrative Review.International journal of general medicine · 2021Review
- Small Fiber Polyneuropathy May Be a Nexus Between Autonomic Nervous System Dysregulation and Pain in Interstitial Cystitis/Bladder Pain Syndrome.Frontiers in pain research (Lausanne, Switzerland) · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Menstrual pain, also known as dysmenorrhea, is a leading risk factor for bladder pain syndrome (BPS). A better understanding of the mechanisms that predispose dysmenorrheic women to BPS is needed to develop prophylactic strategies. Abnormal autonomic regulation, a key factor implicated in BPS and chronic pain, has not been adequately characterized in women with dysmenorrhea. Thus, we examined heart rate variability (HRV) in healthy (n = 34), dysmenorrheic (n = 103), and BPS participants (n = 23) in their luteal phase across a bladder-filling task. Both dysmenorrheic and BPS participants reported increased bladder pain sensitivity when compared to controls (p's < 0.001). Similarly, dysmenorrheic and BPS participants had increased heart rate (p's < 0.01), increased diastolic blood pressure (p's < 0.01), and reduced HRV (p's < 0.05) when compared to controls. Dysmenorrheic participants also exhibited little change in heart rate between maximum bladder capacity and after micturition when compared to controls (p = 0.013). Our findings demonstrate menstrual pain's association with abnormal autonomic activity and bladder sensitivity, even two weeks after menses. Our findings of autonomic dysfunction in both early episodic and chronic visceral pain states points to an urgent need to elucidate the development of such imbalance, perhaps beginning in adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.