ArticleThe Indian journal of medical research2018
Molecular genotyping of clinically important blood group antigens in patients with thalassaemia.
Article in The Indian journal of medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Clinical integration of red cell genotyping in children with β-thalassemia major: a prospective observational study.Blood global hematology · 2026Article
- Association between HLA-DRB1*04, HLA-DQB1*03, and HLA-DQB1*06 with alloimmunization in transfusion-dependent patients with thalassemia: the first case-control study in Iran.Annals of hematology · 2025Article
- Determining theInternational journal of hematology-oncology and stem cell research · 2025Article
- The Distribution Patterns of Rhesus (Rh) Antigens.Cureus · 2024Article
- Molecular characterization of rare D--/D-- variants in individuals of Indian origin.Blood transfusion = Trasfusione del sangue · 2022Article
- Blood group genotyping in alloimmunized multi-transfused thalassemia patients from Iran.Molecular genetics & genomic medicine · 2021Article
- Article
- Red cell antigen phenotypes in blood donors & thalassaemia patients for creation of red cell antigen-matched inventory.The Indian journal of medical research · 2020Article
- A cross-sectional pilot study to estimate the frequency of minor blood group alleles and phenotypes in RhD-negative North Indian blood donors by DNA microarray analysis.Asian journal of transfusion scienceArticle
- Molecular typing of Kell, Kidd, and Duffy antigens in direct antiglobulin test-positive autoimmune hemolytic anemia patients.Asian journal of transfusion scienceArticle
- A comparison of serological phenotyping and molecular genotyping for Kell, Kidd, and Duffy antigens in multi-transfused thalassemia patients.Asian journal of transfusion scienceArticle
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesIn multitransfused thalassaemic patients, haemagglutination fails to phenotype the patient's blood group antigens due to the presence of donor-derived erythrocytes. DNA-based methods can overcome the limitations of haemagglutination and can be used to determine the correct antigen profile of these patients. This will facilitate the procurement of antigen-matched blood for transfusion to multitransfused patients. Thus, the aim of this study was to compare the serological phenotyping of common and clinically important antigens of Rh, Duffy, Kell, Kidd and MNS blood group systems with molecular genotyping amongst multitransfused thalassaemic patients.
methodsBlood samples from 200 patients with thalassaemia and 100 'O' group regular blood donors were tested using standard serological techniques and polymerase chain reaction-based methods for common antigens/alleles (C, c, D, E, e, Fy
resultsGenotyping and phenotyping results were discordant in 77 per cent of thalassaemic patients for five pairs of antithetical antigens of Rh, Duffy, Kell and Kidd blood group systems. In the MNS blood group system, 59.1 per cent of patients showed discrepancy. The rate of alloimmunization among thalassaemics was 7.5 per cent. INTERPRETATION &
conclusionsMolecular genotyping enabled the determination of the actual antigen profile in multitransfused thalassaemia patients. This would help reduce the problem of alloimmunization in such patients and would also aid in the better management of transfusion therapy.
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