Evidence map›Paper›PMID 30777982›Full record

ArticleIndian journal of ophthalmology2019

Retinoblastoma discordance in families with twins.

Aloysius Abraham, Kannan Thirumalairaj, Namrata Gaikwad, Veerappan Muthukkaruppan, Alla G Reddy, Kumarasamy Thangaraj, Usha Kim, Ayyasamy Vanniarajan

Open access · diamondAbstract readCase ReportsTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Aloysius AbrahamDepartment of Molecular Genetics, Aravind Medical Research Foundation, Madurai, India.
Kannan ThirumalairajDepartment of Molecular Genetics, Aravind Medical Research Foundation, Madurai, India.
Namrata GaikwadDepartment of Orbit, Oculoplasty and Oncology, Aravind Eye Hospital, Madurai, India.
Veerappan MuthukkaruppanDepartment of Immunology and Stem Cell Biology, Aravind Medical Research Foundation, Madurai, India.
Alla G ReddyCouncil of Scientific and Industrial Research Centre for Cellular and Molecular Biology, Hyderabad, India.
Kumarasamy ThangarajCouncil of Scientific and Industrial Research Centre for Cellular and Molecular Biology, Hyderabad, India.
Usha KimDepartment of Orbit, Oculoplasty and Oncology, Aravind Eye Hospital, Madurai, India.
Ayyasamy VanniarajanDepartment of Molecular Genetics, Aravind Medical Research Foundation, Madurai, India.
Aravind Eye Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retinoblastoma has an increased inheritance risk of germline RB1 mutations in offspring and siblings, especially twins. Three families, each having one retinoblastoma-affected twin, were selected for genetic analysis and DNA profiling. Germline RB1 mutations were found in all probands. DNA profiling carried on similar-looking twins of families I and II, proved them to be fraternal. This study demonstrates the importance of genetic analysis of RB1 gene for risk prediction in retinoblastoma families. It also emphasizes that DNA profiling is a mandate for genetic screening of families with twins, thus adding a new dimension in counseling of retinoblastoma.

Indexed as

Diseases in TwinsDNAFemaleGenes, RetinoblastomaGenetic TestingGerm-Line MutationHumansInfantMicroscopy, AcousticPedigreeRetinal NeoplasmsRetinoblastomaDNADNA profilinggenetic analysisretinoblastomaRetinoblastoma 1 (RB1) genetwins

Identifiers

PMID30777982
PMCPMC6407382
OpenAlexW2915861353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.