Evidence map›Paper›PMID 30777898›Full record

ReviewThorax2019

Help, hinder, hide and harm: what can we learn from the interactions between

Dominique Hope Limoli, Lucas R Hoffman

Open access · hybridAbstract readReview
In one paragraph

Review in Thorax, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 135 citations in OpenAlex.

  1. The effect ofiScience · 2026
    Article
  2. ERJ open research · 2026
    Review
  3. Review
  4. Article
  5. NorA and Tet38 efflux pumps enableAntimicrobial agents and chemotherapy · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Orthopaedic infections: novel treatment strategies and evolving concepts.OTA international : the open access journal of orthopaedic trauma · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. mBio · 2024
    Article
  14. Article
  15. Mutations in thebioRxiv : the preprint server for biology · 2024
    Article
  16. bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
  18. Article
  19. Frontiers in cellular and infection microbiology · 2024
    Article
  20. Unveiling the modulation ofFrontiers in microbiology · 2024
    Article

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Dominique Hope LimoliMicrobiology and Immunology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, Iowa, USA.ORCID 0000-0002-4130-337X
Lucas R HoffmanDepartments of Pediatrics and Microbiology, University of Washington, Seattle, Washington, USA.
University of Iowa · USUniversity of Washington · US

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI PRADEEP k SINGH · 2010 to 2026
$21.4M
Patient-oriented microbiome and advanced culture approaches to identifying the microbial determinants of chronic pediatric diseaseK24HL141669 · NHLBI · UNIVERSITY OF WASHINGTON · PI Lucas R Hoffman · 2018 to 2026
$929k
NHLBI NIH HHS K24 HL141669NIDDK NIH HHS P30 DK089507
6 · The paper itself

Abstract

Recent studies of human respiratory secretions using culture-independent techniques have found a surprisingly diverse array of microbes. Interactions among these community members can profoundly impact microbial survival, persistence and antibiotic susceptibility and, consequently, disease progression. Studies of polymicrobial interactions in the human microbiota have shown that the taxonomic and structural compositions, and resulting behaviours, of microbial communities differ substantially from those of the individual constituent species and in ways of clinical importance. These studies primarily involved oral and gastrointestinal microbiomes. While the field of polymicrobial respiratory disease is relatively young, early findings suggest that respiratory tract microbiota members also compete and cooperate in ways that may influence disease outcomes. Ongoing efforts therefore focus on how these findings can inform more 'enlightened', rational approaches to combat respiratory infections. Among the most common respiratory diseases involving polymicrobial infections are cystic fibrosis (CF), non-CF bronchiectasis, COPD and ventilator-associated pneumonia. While respiratory microbiota can be diverse, two of the most common and best-studied members are

Indexed as

BronchiectasisCoinfectionCystic FibrosisHumansMicrobial InteractionsPneumonia, Ventilator-AssociatedPrognosisPseudomonas aeruginosaPseudomonas InfectionsRespiratory Tract InfectionsStaphylococcal InfectionsStaphylococcus aureusbacterial infectioncystic fibrosispaediatric lung disaeserespiratory infection

Identifiers

PMID30777898
PMCPMC6585302
OpenAlexW2911732387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.