Evidence map›Paper›PMID 30777879›Full record

ArticleMolecular cancer research : MCR2019

MCL1 and DEDD Promote Urothelial Carcinoma Progression.

Andrew L Hong, Jennifer L Guerriero, Mihir B Doshi, Bryan D Kynnap, Won Jun Kim, Anna C Schinzel, Rebecca Modiste, Amy J Schlauch, Rosalyn M Adam, David J Kwiatkowski and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Andrew L HongBoston Children's Hospital, Boston, Massachusetts.ORCID 0000-0003-0374-1667
Jennifer L GuerrieroDana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-2104-5457
Mihir B DoshiBroad Institute of Harvard and MIT, Cambridge, Massachusetts.
Bryan D KynnapDana-Farber Cancer Institute, Boston, Massachusetts.
Won Jun KimDana-Farber Cancer Institute, Boston, Massachusetts.
Anna C SchinzelDana-Farber Cancer Institute, Boston, Massachusetts.
Rebecca ModisteDana-Farber Cancer Institute, Boston, Massachusetts.
Amy J SchlauchDana-Farber Cancer Institute, Boston, Massachusetts.
Rosalyn M AdamBoston Children's Hospital, Boston, Massachusetts.ORCID 0000-0002-0943-6236
David J KwiatkowskiDana-Farber Cancer Institute, Boston, Massachusetts.ORCID 0000-0002-5668-5219
Rameen BeroukhimDana-Farber Cancer Institute, Boston, Massachusetts.
Anthony LetaiDana-Farber Cancer Institute, Boston, Massachusetts.
Jonathan E Rosenberg *Memorial Sloan Kettering Cancer Center, New York, New York.
William C Hahn *Dana-Farber Cancer Institute, Boston, Massachusetts. william_hahn@dfci.harvard.edu.
Dana-Farber Cancer Institute · USBroad Institute · USBoston Children's Hospital · USBrigham and Women's Hospital · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI A. Heather Eliassen · 1985 to 2026
$330.6M
Treating the P13-Kinase/AKTP50CA101942 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Wanling Xie · 2003 to 2026
$53.4M
The Child Heath Research CenterK12HD052896 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Wendy K Chung · 2007 to 2026
$7.9M
Research Training in Pediatric OncologyT32CA136432 · NCI · DANA-FARBER CANCER INST · PI SCOTT A ARMSTRONG · 2009 to 2026
$7.9M
The Dana-Farber Cancer Institute Cancer Target Discovery and Development CenterU01CA176058 · NCI · DANA-FARBER CANCER INST · PI HAHN, WILLIAM C. · 2013 to 2021
$7.8M
Evaluation of a novel urothelial cancer biomarker of lethalityR21CA164613 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ROSENBERG, JONATHAN ERIC · 2012 to 2013
$454k
Harnessing anti-tumor macrophages for cancer therapyF32CA180733 · NCI · DANA-FARBER CANCER INST · PI GUERRIERO, JENNIFER L. · 2013 to 2015
$165k
NCI NIH HHS F32 CA180733NCI NIH HHS P30 CA006516NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA101942NCI NIH HHS R21 CA164613NCI NIH HHS T32 CA136432NCI NIH HHS U01 CA176058NICHD NIH HHS K12 HD052896
6 · The paper itself

Abstract

Focal amplification of chromosome 1q23.3 in patients with advanced primary or relapsed urothelial carcinomas is associated with poor survival. We interrogated chromosome 1q23.3 and the nearby focal amplicon 1q21.3, as both are associated with increased lymph node disease in patients with urothelial carcinoma. Specifically, we assessed whether the oncogene

Indexed as

AnimalsApoptosisCell Line, TumorCell ProliferationDeath Domain Receptor Signaling Adaptor ProteinsDisease ProgressionDNA-Binding ProteinsFemaleHumansMiceMyeloid Cell Leukemia Sequence 1 ProteinUrinary Bladder NeoplasmsUrotheliumDeath Domain Receptor Signaling Adaptor ProteinsDEDD protein, humanDNA-Binding ProteinsMCL1 protein, humanMyeloid Cell Leukemia Sequence 1 Protein

Identifiers

PMID30777879
PMCPMC6548646
OpenAlexW2917177898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.