Evidence map›Paper›PMID 30777851›Full record

ArticleCancer research2019

A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma.

Daniel M Lewis, Hawley Pruitt, Nupur Jain, Mark Ciccaglione, J Michael McCaffery, Zhiyong Xia, Kristy Weber, T S Karin Eisinger-Mathason, Sharon Gerecht

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

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  16. The role of collagen in cancer: from bench to bedside.Journal of translational medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Daniel M LewisDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, Maryland.
Hawley PruittDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, Maryland.
Nupur JainDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, Maryland.
Mark CiccaglioneDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, Maryland.
J Michael McCafferyDepartment of Biology and Integrated Imaging Center, Johns Hopkins University, Baltimore, Maryland.
Zhiyong XiaApplied Physics Laboratory, Johns Hopkins University, Laurel, Maryland.
Kristy WeberDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-8021-011X
T S Karin Eisinger-MathasonSarcoma Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Sharon GerechtDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology, Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, Maryland. gerecht@jhu.edu.
Johns Hopkins University · USUniversity of Pennsylvania · USJohns Hopkins University Applied Physics Laboratory · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2016 to 2020
$9.9M
T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
T-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCMT32CA130840 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2008 to 2012
$1.2M
NCI NIH HHS P30 CA006973NCI NIH HHS T32 CA130840NCI NIH HHS T32 CA153952NCI NIH HHS U54 CA210173
6 · The paper itself

Abstract

Upregulation of collagen matrix crosslinking directly increases its ability to relieve stress under the constant strain imposed by solid tumor, a matrix property termed stress relaxation. However, it is unknown how rapid stress relaxation in response to increased strain impacts disease progression in a hypoxic environment. Previously, it has been demonstrated that hypoxia-induced expression of the crosslinker procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), in sarcomas has resulted in increased lung metastasis. Here, we show that short stress relaxation times led to increased cell migration along a hypoxic gradient in 3D collagen matrices, and rapid stress relaxation upregulated PLOD2 expression via TGFβ-SMAD2 signaling, forming a feedback loop between hypoxia and the matrix. Inhibition of this pathway led to a decrease in migration along the hypoxic gradients.

Indexed as

Cell MovementGene Expression Regulation, NeoplasticAnimalsApoptosisCell ProliferationCollagenExtracellular MatrixHumansHypoxiaLung NeoplasmsMiceMice, NudeNeoplasm InvasivenessOxygenProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenaseRheologyCollagenOxygenPLOD2 protein, humanProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenaseSmad2 ProteinSMAD2 protein, humanTGFB1 protein, humanTransforming Growth Factor beta1

Identifiers

PMID30777851
PMCPMC6727644
OpenAlexW2915516112

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.