Evidence map›Paper›PMID 30777730›Full record

ArticleBlood cells, molecules & diseases2019

Ferritin in serum and urine: A pilot study.

Timothy M Bahr, Robert D Christensen, Diane M Ward, Fanjing Meng, Laurie K Jackson, Kelly Doyle, Daniel R Christensen, Anne G Harvey, Hassan M Yaish

Open access · greenAbstract read
In one paragraph

Article in Blood cells, molecules & diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Anemia, Iron Supplementation, and the Brain.Clinics in perinatology · 2023
    Review
  11. A novel view of ferritin in cancer.Biochimica et biophysica acta. Reviews on cancer · 2023
    Review
  12. Article
  13. Article
  14. Urinary ferritin; a potential noninvasive way to screen NICU patients for iron deficiency.Journal of perinatology : official journal of the California Perinatal Association · 2021
    Article
  15. Review
  16. Ferritins in Kidney Disease.Seminars in nephrology · 2020
    Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Timothy M BahrDivision of Neonatology, University of Utah, Salt Lake City, UT, USA. Electronic address: Tim.Bahr@hsc.utah.edu.
Robert D ChristensenDivision of Neonatology, University of Utah, Salt Lake City, UT, USA; Center for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA; Women and Newborn's Clinical Program, Intermountain Healthcare, Salt Lake City, UT, USA; Division of Hematology/Oncology, University of Utah, Salt Lake City, UT, USA.
Diane M WardCenter for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Fanjing MengDepartment of Pathology, University of Utah, Salt Lake City, UT, USA.
Laurie K JacksonCenter for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA; Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Kelly DoyleDepartment of Pathology, University of Utah, Salt Lake City, UT, USA; Central Laboratories, Intermountain Medical Center, Murray, UT, USA.
Daniel R ChristensenDivision of Neonatology, University of Utah, Salt Lake City, UT, USA.
Anne G HarveyDivision of Hematology/Oncology, University of Utah, Salt Lake City, UT, USA.
Hassan M YaishDivision of Hematology/Oncology, University of Utah, Salt Lake City, UT, USA.
University of Utah · US

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
FACTORS REGULATING THE CELLULAR UPTAKE OF IRONR37DK030534 · NIDDK · UNIVERSITY OF UTAH · PI KAPLAN, JERRY · 2000 to 2009
$3.3M
FACTORS REGULATING THE CELLULAR UPTAKE OF IRONR01DK030534 · NIDDK · UNIVERSITY OF UTAH · PI WARD, DIANE MCVEY · 1986 to 2018
$2.7M
NIDDK NIH HHS R01 DK030534NIDDK NIH HHS R37 DK030534NIDDK NIH HHS U54 DK110858
6 · The paper itself

Abstract

Serum ferritin reflects total body iron stores, thus a low serum ferritin is used as a parameter of iron deficiency. In healthy adults in Japan, urine ferritin levels were about 5% of serum ferritin levels, with a correlation coefficient of 0.79. It is not known whether a low urine ferritin could serve as a non-invasive screen for iron deficiency. If so, this might be useful for neonates and young children, avoiding phlebotomy to screen for iron deficiency. However, for urinary ferritin screening to be feasible, ferritin must be measurable in the urine and correlate with serum ferritin. Testing should also clarify whether the iron content of ferritin in serum and urine are similar. In this pilot feasibility study we measured ferritin in paired serum and urine samples of healthy adult males, healthy term neonates, growing preterm neonates, and children who had very high serum ferritin levels from liver disorders or iron overload. We detected ferritin in every urine sample, and found a correlation with paired serum ferritin (Spearman correlation coefficient 0.78 of log

Indexed as

AdultAnemia, Iron-DeficiencyChildFerritinsHumansInfant, NewbornJapanLiver DiseasesMaleMass ScreeningPilot ProjectsFerritinsFerritinIronIron deficiencySerumUrine

Identifiers

PMID30777730
PMCPMC6420832
OpenAlexW2911860351

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.