Evidence map›Paper›PMID 30777693›Full record

ArticleJournal of vascular surgery2019

Effects of a novel hydrogen sulfide prodrug in a porcine model of acute limb ischemia.

Amanda M Rushing, Erminia Donnarumma, David J Polhemus, Kevin R Au, Samuel E Victoria, Jeffrey D Schumacher, Zhen Li, J Stephen Jenkins, David J Lefer, Traci T Goodchild

Open access · greenAbstract read
In one paragraph

Article in Journal of vascular surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. HBiomolecules · 2024
    Article
  2. Article
  3. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  4. Review
  5. HBiomedicines · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. HBiomedicines · 2021
    Review
  11. Endothelium as a Source and Target of HAntioxidants (Basel, Switzerland) · 2021
    Review
  12. Review
  13. Review
  14. Acute Lower Limb Ischemia-Etiology, Pathology, and Management.The International journal of angiology : official publication of the International College of Angiology, Inc · 2020
    Review
  15. Article
  16. Reactive Sulfur Species: A New Redox Player in Cardiovascular Pathophysiology.Arteriosclerosis, thrombosis, and vascular biology · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Amanda M RushingCardiovascular Center of Excellence, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
Erminia DonnarummaCardiovascular Center of Excellence, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
David J PolhemusCardiovascular Center of Excellence, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La; Department of Pharmacology, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
Kevin R AuDepartment of Vascular Surgery, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
Samuel E VictoriaDepartment of Vascular Surgery, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
Jeffrey D SchumacherDepartment of Animal Care, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
Zhen LiCardiovascular Center of Excellence, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La; Department of Pharmacology, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
J Stephen JenkinsHeart and Vascular Institute, Ochsner Medical Center, New Orleans, La.
David J LeferCardiovascular Center of Excellence, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La; Department of Pharmacology, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La.
Traci T GoodchildCardiovascular Center of Excellence, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La; Department of Pharmacology, Louisiana State University Health Sciences Center-New Orleans, New Orleans, La. Electronic address: tgoodc@lsuhsc.edu.
Louisiana State University Health Sciences Center New Orleans · USOchsner Medical Center · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
Preclinical Consortium to Facilitate Translation of Cardioprotective TherapiesU24HL094373 · NHLBI · UNIVERSITY OF LOUISVILLE · PI BOLLI, ROBERTO · 2010 to 2014
$9.6M
Functional Cardio-MetabolomicsP20HL113452 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2012 to 2016
$4.8M
Cardioprotective Actions of Hydrogen SulfideR01HL092141 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2013
$1.9M
Nitrite Mediated CardioprotectionR01HL093579 · NHLBI · LSU HEALTH SCIENCES CENTER · PI LEFER, DAVID JOSEPH · 2009 to 2012
$1.5M
NHLBI NIH HHS P20 HL113452NHLBI NIH HHS R01 HL092141NHLBI NIH HHS R01 HL093579NHLBI NIH HHS U24 HL094373NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

objectivePrevious studies have shown that hydrogen sulfide (H

methodsALI was induced in 17 female miniswine via intravascular occlusion of the external iliac. At day 7 after ALI induction, miniswine (n = 17) were randomized to received placebo or the H

conclusionsOur results suggest that daily administration of the H

Indexed as

Acute DiseaseAngiogenesis Inducing AgentsAnimalsCoronary VesselsDisease Models, AnimalExtremitiesFemaleHydrogen SulfideIschemiaNeovascularization, PhysiologicNitric OxideNitritesOxidative StressPeripheral Arterial DiseaseProdrugsRegional Blood FlowAngiogenesis Inducing AgentsHydrogen SulfideNitric OxideNitritesProdrugsAcute limb ischemiaHydrogen sulfideNitric oxidePeripheral artery diseaseSwine

Identifiers

PMID30777693
PMCPMC6548642
OpenAlexW2912371173

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.