Evidence map›Paper›PMID 30777653›Full record

ArticleParkinsonism & related disorders2019

Genetic variants in nicotinic receptors and smoking cessation in Parkinson's disease.

Yu-Hsuan Chuang, Kimberly C Paul, Janet S Sinsheimer, Jeff M Bronstein, Yvette M Bordelon, Beate Ritz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Update: Protective and risk factors for Parkinson disease.Parkinsonism & related disorders · 2024
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yu-Hsuan ChuangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA. Electronic address: ychuan3@ucla.edu.
Kimberly C PaulDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA. Electronic address: kimberlyc.paul@gmail.com.
Janet S SinsheimerDepartment of Human Genetics and Biomathematics, UCLA David Geffen School of Medicine, Department of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, CA, USA. Electronic address: janets@mednet.ucla.edu.
Jeff M BronsteinDepartment of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: JBronste@mednet.ucla.edu.
Yvette M BordelonDepartment of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA. Electronic address: ybordelon@mednet.ucla.edu.
Beate RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA; Department of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA; Department of Environmental Health, UCLA Fielding School of Public Health, Los Angeles, CA, USA. Electronic address: britz@ucla.edu.
University of California, Los Angeles · USUCLA Health · US

Funding

Center for Gene-Environment Studies in Parkinson DiseaseU54ES012078 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 2002 to 2006
$7.1M
Project 4: Pesticides and Genes In PD: Studies In HumansP01ES016732 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHESSELET, MARIE-FRANCOISE S · 2008 to 2012
$6.7M
PARKINSON'S DISEASES SUSCEPTIBILITY GENES AND PESTICIDESR01ES010544 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2000 to 2015
$5.7M
Environmental Predictors of the Overlap of Neurodegenerative Disorders and Metabolic DysfunctionF32ES028087 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL, KIMBERLY · 2017 to 2018
$121k
NIEHS NIH HHS F32 ES028087NIEHS NIH HHS P01 ES016732NIEHS NIH HHS R01 ES010544NIEHS NIH HHS U54 ES012078
6 · The paper itself

Abstract

backgroundNegative associations between smoking and Parkinson's disease (PD) are well documented. While common biases may not explain this association, some studies have suggested reverse causality and ease of quitting might be an early sign of PD, possibly related to a reduced nicotinic response. We investigated nicotinic receptor (nAChR) genetics to add to our understanding of possible biologic mechanisms underlying the smoking-PD relationship.

methodsWe relied on 612 patients and 691 controls enrolled in the PEG (Parkinson's Environment and Gene) study for whom we obtained information on smoking and quitting ease through interviews. Genotyping in the nAChR genes, i.e. CHRNA5-A3-B4 and CHRNB3-A6 gene regions that have been linked to smoking or quitting behaviors, were based on blood and saliva DNA samples. We assessed associations with logistic regression assuming logit-additive allelic effects and used product terms for genetic allele status and smoking or quitting assessing interactions.

resultsAs expected, we observed negative associations between smoking and PD that were strongest for current followed by former smokers. In former smokers, high quitting difficulty was negatively associated with PD risk (extremely hard vs. easy: OR = 0.62 [0.39-0.99], p = 0.05), meaning those who developed PD were able to quit smoking with less difficulty than controls. The CHRNA3 rs578776-A allele predicted quitting difficulty in smoking controls (OR = 0.53 [0.32-0.91], p = 0.02), but not in smoking PD patients (OR = 1.09 [0.61-1.95], p = 0.77).

conclusionOur study further corroborates previous findings that ease of quitting may be an early sign of PD onset related to a loss of nicotinic response in prodromal stages.

Indexed as

AdultAgedAged, 80 and overAllelesFemaleGenetic Association StudiesHumansMaleMiddle AgedNerve Tissue ProteinsParkinson DiseasePolymorphism, Single NucleotideReceptors, NicotinicSmokingSmoking CessationNerve Tissue ProteinsReceptors, NicotinicCHRNA3Nicotinic receptor (nAChR)Parkinson's diseaseSmoking cessation

Identifiers

PMID30777653
PMCPMC6589367
OpenAlexW2912107346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.